The efficacy of multiple courses of alefacept in patients with moderate to severe chronic plaque psoriasis |
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Authors: | Menter Alan Cather Jennifer C Baker Diane Farber Harold F Lebwohl Mark Darif Mohamed |
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Affiliation: | Baylor University Medical Center, Dallas, Texas, USA. amresearch@texasderm.com |
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Abstract: | Among patients with psoriasis who did not achieve Psoriasis Area and Severity Index 50 during the first course of alefacept therapy, 53% achieved Psoriasis Area and Severity Index 50 during the second course (odds ratio [95% confidence interval] vs placebo 2.30 [1.26-4.19]). Alefacept provided incremental efficacy over 5 successive 12-week treatment courses. |
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