| Implications of Stem Cells and Cancer Stem Cells for Understanding Fomation and Therapy of Cancer |
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| 引用本文： | Guanghui Li Donglin Wang. Implications of Stem Cells and Cancer Stem Cells for Understanding Fomation and Therapy of Cancer[J]. 中国肿瘤临床(英文版), 2005, 2(4): 751-757. DOI: 10.1007/BF02819542 |
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| 作者姓名： | Guanghui Li Donglin Wang |
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| 作者单位： | [1]The PLA Center for Cancer Treatment, Xinqiao Hospital of the Third Military Medical University,Chongqing 400037, China |
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| 摘 要： |
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| 关 键 词： | 干细胞 肿瘤细胞 治疗方法 细胞增生 |
| 收稿时间： | 2005-01-31 |
| 修稿时间： | 2005-06-14 |
Implications of stem cells and cancer stem cells for understanding fomation and therapy of cancer |
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| Guanghui Li,Donglin Wang. Implications of stem cells and cancer stem cells for understanding fomation and therapy of cancer[J]. Chinese Journal of Clinical Oncology, 2005, 2(4): 751-757. DOI: 10.1007/BF02819542 |
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| Authors: | Guanghui Li Donglin Wang |
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| Affiliation: | The PLA Center for Cancer Treatment,Xinqiao Hospital of the Third Military Medical University,Chongqing 400037, China |
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| Abstract: | Most cancers are heterogeneous with respect to proliferation and differentiation. There is increasing evidence suggesting that only a minority of cancer cells, tumorigenic or tumor initiating cells, possess the capacity to proliferate extensively and form new hematopoietic cancer or solid tumors. Tumor initiating cells share characteristics required for normal stem cells. The dysregulation of self-renewal and proliferation of stem cells is a likely requirement for cancer development. This review formulates a model for the origin of cancer stem cells and regulating self-renewal which influences the way we study and treat cancer. |
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| Keywords: | cancer stem cells self-renewal proliferation stem cells |
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