| 冠状动脉结扎法建立小鼠心肌梗死模型的病理及心功能变化观察 |
| |
| 引用本文： | 卢晓梅,王巍,杜莉莉,金玉楠,张立敏,于艳秋.冠状动脉结扎法建立小鼠心肌梗死模型的病理及心功能变化观察[J].中国医科大学学报,2006,35(1):13-14. |
| |
| 作者姓名： | 卢晓梅 王巍 杜莉莉 金玉楠 张立敏 于艳秋 |
| |
| 作者单位： | 1. 中国医科大学基础医学院病理生理学教研室,辽宁,沈阳,110001
2. 中国医科大学基础医学院附属第一医院心功能科 |
| |
| 摘 要： | 目的：观察小鼠心肌梗死模型的病理与心功能变化。方法：缝扎小鼠冠状动脉左前降支，观察超声心动图变化及心肌组织病理变化情况。结果：小鼠结扎后，左室舒张末、收缩末内径增大；短轴缩短率、射血分数降低。病理切片提示心肌缺血后早期可见大量的炎性细胞浸润及心肌细胞膜不完整表现，晚期可见心肌纤维断裂、心肌细胞坏死。结论：冠状动脉结扎法可成功建立小鼠心肌梗死模型。
|
| 关 键 词： | 冠状动脉结扎 心肌梗死 小鼠 |
| 文章编号： | 0258-4646(2006)01-0013-02 |
| 收稿时间： | 2005-11-02 |
| 修稿时间： | 2005年11月2日 |
Changes of pathology and cardiac function in murine myocardial infarction model established by coronary artery ligation |
| |
| LU Xiao-mei,WANG Wei,DU Li-li,JIN Yu-nan,ZHANG Li-min,YU Yan-qiu.Changes of pathology and cardiac function in murine myocardial infarction model established by coronary artery ligation[J].Journal of China Medical University,2006,35(1):13-14. |
| |
| Authors: | LU Xiao-mei WANG Wei DU Li-li JIN Yu-nan ZHANG Li-min YU Yan-qiu |
| |
| Institution: | 1. Department of Pathophysiolegy, College of Basic Medical Sciences, China Medical University, Shenyang 110001, China; 2. Department of Cardiac Function, The First Affiliated Hoepital |
| |
| Abstract: | Objective: To study the changes of pathology and cardiac function in murine myocardial infarction model by using coronary artery ligation.Methods: The left anterior descending coronary artery was ligated.The changes of echocardiography and myocardial pathology were observed.Results: After coronary artery ligation,the left ventricular end-diastolic and end-systolic diameters increased,and the fractional shortening(FS) and ejection fraction(EF) decreased.In the early stage of myocardial ischemia,the inflammatory cells infiltrated,and the membranes of cardiac myocytes were incomplete.In the late stage,the myocardial fiber was fractured,and cardiac myocytes were necrotic.Conclusion: Murine myocardial infarction model could be established successfully by coronary artery ligation. |
| |
| Keywords: | coronary artery ligation myocardial infarction mice |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
