骨髓增生异常综合征与再生障碍性贫血并发自身免疫性疾病的临床分析

 目的　探讨骨髓增生异常综合征（MDS）与再生障碍性贫血（AA）并发自身免疫性疾病（AID）的发病特点及治疗学特点。方法　对该院111例MDS患者与56例AA患者的临床资料进行回顾性分析与随访观察。结果　111例MDS患者中有9例并发AID（8.1 %），56例AA患者中有2例并发AID（3.6 ％），并发的AID以自身免疫性溶血性贫血（36.4 ％）与白塞病（18.2 ％）多见。5例患者AID发病在前，4例患者MDS和（或）AA与AID同时发病，2例患者MDS发病后3年并发AID。结论　MDS和（或）AA与AID具有一定的内在相关性。

A clinical analysis of myelodysplastic syndrome and aplastic anemia combined with autoimmune disease

Objective To investigate the characteristics of pathogenesis and therapeutics of myelodysplastic syndrome(MDS)and aplastic anemia(AA)combined with autoimmune disease(AID).Methods Retrospective analysis and follow-up visit of 111 patients with MDS and 56 patients with AA in our hospital were studied.Results There were 9(8.1%)of 111 patients with MDS and 2 (3.6%)of 55 patients with AA coexistent with AID.Autoimmune hemolytic anemia(36.4%)and Behcet Disease(18.2%)were common among those combined with AID.5 patients had AID proceeding to the occurrence of MDS/AA.4 patients had simultaneous occurrence of AID and MDS/AA.2 patients developed AID three years later after the diagnosis of MDS.Conclusion There was a certain intrinsic relationship between MDS/AA and AID.