Tribulin in post-traumatic stress disorder |
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Authors: | J Davidson V Glover A Clow H Kudler K Meador M Sandler |
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Affiliation: | Department of Psychiatry, Duke University Medical Center, Durham, North Carolina. |
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Abstract: | Tribulin (endogenous monoamine oxidase inhibitor/benzodiazepine receptor binding inhibitor) output was measured in the urine of 18 patients with post-traumatic stress disorder (PTSD) and 13 controls. The level of the two inhibitory activities was highly significantly correlated in the group as a whole. There was no difference between output of either inhibitor in patients and controls. However, when the PTSD group was subdivided according to various psychometric ratings, a pattern of output did emerge. Levels of both inhibitory activities were higher in agitated compared with non-agitated subjects, and lower in extroverts compared with introverts. This finding supports the view that tribulin output is raised in conditions of greater arousal. |
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