乌司他丁影响膀胱引流式犬胰腺移植Oddi括约肌功能的研究

目的:研究乌司他丁(US)对膀胱引流式犬胰腺移植后移植物Oddi括约肌(SO)功能的影响。方法:正常犬和膀胱引流式胰腺移植后犬在应用US 10万U和30万U前后测定SO的动力学指标。结果:US对正常犬SO基础压和收缩幅度无明显影响(P>0.05),但可降低其收缩频率和动力指数(P<0.01);在10万U和30万U剂量间,动力指数有统计学差异(P<0.01),收缩频率则无统计学差异(P>0.05);移植后应用US可全面降低SO基础压、收缩频率、收缩幅度和动力指数(P<0.01),且在10万U与30万U剂量间差异均有显著性 (P<0.05)。结论:US可抑制犬SO运动, 并呈剂量依赖性;尤其胰腺移植后,抑制作用更显著,可以有效地降低基础压,改善胰液引流,从而有助于防治移植物胰腺炎的发生。

The effect of ulinastatin on Oddi sphincter of dogs after pancreatic transplantation

Objective To investigate the effect of ulinastatin on Oddi sphincter after pancreatic transplantation in the dog.Methods Ten thousand and thirty thousand units ulinastatin were injected into normal dogs and dogs undergoing pancreatic transplantation,and then the pressure of Oddi sphincter was measured.Results In normal dogs,there was no significant difference between basic pressure and contraction pressure(P>0.05),but the contraction frequency and kinetic index were both decreased(P<0.01).The kinetic index when injecting ten thousand units ulinastatin was stastically different to that when injecting thirty thousand units ulinastatin(P<0.01),but there was no difference in contraction frequency(P>0.05).In pancreas transplantation dogs,the basic pressure,contraction frequency and kinetic index were all decreased with usage of ulinastatin(P<0.01)and there was a difference between the ulinastatin dosage of ten thousand units and that of thirty thousand units(P<0.05).Conclusions Ulinastatin could restrain the movement of Oddi sphincter,and this effect had a positive correlation with dosage,especially after pancreatic transplantation.Ulinastatin can effectively reduce basal sphincter pressure,improve the drainage of pancreatic fluid and is conducive to prevention and treatment of pancreatitis after transplantation.