β3-受体基因多态性对减重效果的影响

目的探讨β3-受体基因多态性对减重效果的影响。方法单纯肥胖者（体重指数≥25kg/m2）274例，测定β3-AR基因Trp64Arg的基因频率。并经过强化生化方式减重干预12个月，干预前后测定体脂、血压、血脂、空腹血糖和胰岛素，计算IR指数（HOMA—IR）。结果按照减重程度分组，理想达标组99例，一般达标组128例和未达标组47例。未达标组Arg基因频率显著高于理想达标组（x^2=4．80，P〈0．05）。减重干预前Arg64携带者组腰围、腰臀比、空腹血糖及HOMA—IR均明显高于Trp64纯合子组（均P〈0．05）。减重干预后，Trp64纯合子组体脂、血压、总胆固醇、甘油三酯、空腹胰岛素及HOMA—IR均显著降低（P〈0．05或P〈0．01），Arg64携带者组上述指标中除体重指数较前降低外（P〈0．05），其余各项指标均无显著变化。结论β3～AR基因Trp64Arg变异与强化生活方式干预后减重不易达标有关。

Relationship Between Trp64Arg Mutation in β3 - adrenergic Receptor Gene and Weight Reduction in Simple Obesity

Objective To study the relationship between Trp64Arg mutation in the β3 adrenergic receptor （β3 - AR） gene and weight reduction response in obese subjects. Methods Genotyping of Trp64Arg mutation in the β3 - AR gene was examined in 274 simple obese subjects that receiving a 12 month intensive lifestyle intervention for weight reduction. Before and after intervention, some clinical metabolic parameters, including body mass index, waist circumference, waist-hip ratio, blood pressure, lipid profiles, fasting blood glucose, fasting insulin level and insulin resistance index （HOMA IR） were evaluated. Results The subjects were divided into the achieved optimal - criteria group （n = 99 ）. the achieved basic - criteria group （n = 128） and the non- achieved criteria group （n = 47） according to weight loss amplitude. The allelic frequency of the Trp64Arg mutation in the non - achieved criteria group was significantly higher than that in the achieved optimal- criteria group （X2 -4.80, P〈 0.05 ）. Before weight loss, the waist circumference, waist- hip ratio, fasting blood glucose and HOMA - IR in subjects with the 133 - AR gene Trp64Arg mutation were significantly higher than those without mutation （ all P〈 0.05 ）. After intervention, the body mass index, blood pressure, total cholesterol, triglyceride, fasting insulin and HOMA- IR were significantly decreased in subjects with homozygote of Trp64 （ P〈 0.05 and P〈 0.01 ）. However. subjects with the Trp64Arg mutation did not show significant changes in their metabolic parameters except body mass index. Conclusions The mutation of Trp64Arg in β3 - AR gene is associated with resistance in losing weight through intensive lifestyle intervention.