老年男性代谢综合征与血清IL-10和hs-CRP的关系

目的:探讨老年男性代谢综合征(metabolic syndrome,MS)患者血清白细胞介素10(interleukin-10,IL-10)、高敏C反应蛋白(hish sensitive C reactive protein,hs-CRP)与代谢综合征的关系.方法:70例老年MS患者和30例年龄相匹配的对照者,测量其血压、腰围(waist circumference,WC)、体质量、身高、体质量指数(BMI)、血脂、空腹血糖(fasting plasma glucose,FIG)、空腹血胰岛素(fasting insulin,FINS)、抵抗指数(homeostasis model assessment of insulin resistance,HOMA-IR),以及血清IL-10和ha-CRP水平.血清IL-10浓度用酶联免疫吸附荆法(enzyme linked immunosorbent assay,ELISA)测定,血清hs-CRP水平用乳胶增强免疫比浊法检测.结果:MS组与对照组比较,血清IL-10浓度显著降低(P<0.05).血清hs-CRP浓度显著升高(P<0.05).Pearson相关分析显示在MS组中,IL-10与HOMA-IR(r=-0.684,P=0.000)和FINS(r=-0.742,P=0.000)之间存在负相关;hs-CRP与BMI(r=0.372,P=0.002),HOMA-IR(r=0.276,P=0.021)和FINS(r=0.312,P=0.008)之间存在正相关.Stepwise回归分析提示,在MS组中FINS可能为IL-10的影响因素,BMI和FINS可能为hs-CRP的影响因素.结论:老年男性MS患者血清IL-10浓度显著降低,血清hs-CRP显著升高,提示存在低度慢性炎症.

Association of metabolic syndrome with serum interleukin-10 and high sensitive C reactive protein(hs-CRP) in old men

Objective To explore the association of metabolic syndrome(MS) with serum interleukin-10(IL-10) and high sensitive C reactive protein(hs-CRP) in old men with MS.Methods Seventy patients with MS and 30 age-matched controls were enrolled.Blood pressure,waist circumference(WC),weight,height,body mass index(BMI),lipid-profile,fasting plasma glucose(FPG),fasting plasma insulin(FINS),homeostasis model assessment of insulin resistance(HOMA-IR),the serum IL-10,and hs-CRP levels were measured.The concentration of se...