Assessment of potentially inappropriate medications in elderly according to Beers 2015 and STOPP criteria and their association with treatment satisfaction |
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| Affiliation: | 1. Pharmacology, Clinical Pharmacy and Quality Control Laboratory, Faculty of Pharmacy, Saint-Joseph University of Beirut, Lebanon;2. Faculty of Pharmacy, Saint-Joseph University of Beirut, Lebanon;3. Research Department, Psychiatric Hospital of the Cross, P.O. Box 60096, Jal Eddib, Lebanon;4. Faculty of Medicine and Medical Sciences, Holy Spirit University of Kaslik, Kaslik, Lebanon;5. Faculty of Pharmacy, Lebanese University, Hadath, Lebanon;6. Occupational Health Environment Research Team, U1219 BPH Bordeaux Population Health Research Center Inserm–Université de Bordeaux, Bordeaux, France;7. INSPECT-LB: Institut National de Sante Publique, Epidemiologie Clinique et Toxicologie, Faculty of Public Health, Lebanese University, Beirut, Lebanon;1. Centre d''excellence sur le vieillissement de Québec, CHU de Québec, Québec, Canada;2. Faculté de Pharmacie, Université Laval, Québec, Canada;3. Donald Berman Maimonides Geriatric Centre, Montreal, Quebec, Canada;4. Division of Geriatric Medicine, McGill University, Montreal, Quebec, Canada;5. Faculté des Sciences Infirmiéres, Université Laval, Québec;6. Département de médecine, Faculté de médecine, Université Laval, Québec, Canada;7. Institut universitaire de gériatrie de Montréal, Montréal, Quebec, Canada;8. Département de Médecine Familiale, Faculté de Médecine, Université Laval, Québec, Canada;9. Département de Médecine Sociale et Préventive, Faculté de médecine, Université Laval, Québec (Québec), Canada;10. Centre de recherche sur le vieillissement, Université de Sherbrooke, Sherbrooke, Quebec, Canada;1. UMR INSERM 1027, University of Toulouse III, Toulouse, France;2. Service de Pharmacologie Clinique, Centre Hospitalo-Universitaire de Toulouse (CHU de Toulouse), Toulouse, France;3. Pôle Pharmacie, CHU de Toulouse, Toulouse, France;4. Service d''épidémiologie, CHU de Toulouse, Toulouse, France;5. Gérontopôle de Toulouse, Institut du Vieillissement, Centre Hospitalo-Universitaire de Toulouse, Toulouse, France;6. UMR 7268 ADES, Aix-Marseille Université/EFS/CNRS, Marseille, France;1. Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany;2. Network Aging Research, University of Heidelberg, Heidelberg, Germany;3. Institute of Health Care and Social Sciences, FOM University, Essen, Germany;1. Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD;2. Johns Hopkins Bloomberg School of Public Health, Baltimore, MD;3. Johns Hopkins University Center for Health Services and Outcomes Research, Baltimore, MD;1. Unit of Primary Health Care, Helsinki University Central Hospital, Department of General Practice, University of Helsinki, Helsinki, Finland;2. City of Kouvola, Services for the Aged, Kouvola, Finland;3. Social Services and Health Care Department, City of Helsinki, Finland;4. Head of the Ageing and Services, National Institute for Health and Welfare, Helsinki, Finland;5. Sansom Institute, School of Pharmacy and Medical Sciences, University of South Australia, Adelaide; Centre for Medicine Use and Safety, Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, Melbourne, Australia;6. Geriatric Unit, Department of Internal Medicine, University of Helsinki, Helsinki, Finland |
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| Abstract: | ObjectiveTo assess and compare, according to Beers and STOPP criteria, the frequency and causes of potentially inappropriate medications (PIMs) in elderly, as well as the relationship between PIMs use and patient’s treatment satisfaction, evaluated using the Treatment Satisfaction Questionnaire for Medications (TSQM).Method350 patients (mean age = 73.49 years), taking a total of 1893 medications, were enrolled from community pharmacies.Results6.2% and 20.4% of the medications were inappropriate according to the STOPP and Beers lists respectively; 103 (29.4%) and 210 (60%) patients had at least one PIM according to STOPP and Beers criteria respectively. The most common cause of PIM was a full dose of proton pomp inhibitor for >8 weeks (STOPP) and using a drug that exacerbates/causes syndrome of inappropriate antidiuretic hormone secretion (Beers). The number of medications taken by the participant, advanced age, female gender, prescription of medications for anxiety/depression, ulcers/gastroesophageal reflux, rheumatoid arthritis and epilepsy significantly increased the PIMs number.When using STOPP criteria, all TSQM subscale scores were significantly lower among patients with PIM use compared to those without PIM. The same trend was observed for Beers critertia, with a significant difference reached for side effects and convenience subscales only.ConclusionSelecting the appropriate tools to assess PIMs, prescribers and patient education regarding the risks associated with PIMs, and patient’s perception and satisfaction regarding his treatment, are critical issues to be addressed among older adults. |
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| Keywords: | Older adults Patient satisfaction Beers criteria STOPP criteria Potentially inappropriate medications Geriatrics |
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