| Notch信号通路在自身免疫性疾病中的作用机制研究进展 |
| |
| 引用本文： | 李晓靖,朱文伟,周永明.Notch信号通路在自身免疫性疾病中的作用机制研究进展[J].中国现代医学杂志,2022(20):49-53. |
| |
| 作者姓名： | 李晓靖 朱文伟 周永明 |
| |
| 作者单位： | 1.上海中医药大学，上海 201203;2.上海中医药大学附属岳阳中西医结合医院， 上海 200437 |
| |
| 基金项目： | 国家自然科学基金（No：8167150921，No：81973798)；上海市临床重点专科建设项目（No：shslczdzk05201） |
| |
| 摘 要： | Notch信号通路与多种免疫细胞、传导通路、分子等调控机制密切相关。Notch信号通路在包含类风湿性关节炎、系统性红斑狼疮、系统性硬化症、炎症性肠病等多种自身免疫性疾病发生、发展中发挥着至关重要的作用。该文就Notch信号通路的结构与生理学特征、调控功能及其在自身免疫性疾病中的作用进行相关综述。
|
| 关 键 词： | 自身免疫性疾病 Notch信号通路 调控机制 |
| 收稿时间： | 2022/1/27 0:00:00 |
Research progress of Notch signaling pathway in autoimmune diseases |
| |
| Xiao-jing Li,Wen-wei Zhu,Yong-ming Zhou.Research progress of Notch signaling pathway in autoimmune diseases[J].China Journal of Modern Medicine,2022(20):49-53. |
| |
| Authors: | Xiao-jing Li Wen-wei Zhu Yong-ming Zhou |
| |
| Institution: | 1.Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China;2.Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China |
| |
| Abstract: | Notch signaling pathway is closely related to a variety of regulatory mechanisms in the levels of immune cells, signal transduction pathways and molecules. It has been revealed that Notch signaling pathway plays an important role in the occurrence and progression of various autoimmune diseases, including rheumatoid arthritis, systemic lupus erythematosus, systemic sclerosis, and inflammatory bowel disease. This review summarizes the composition, physiological characteristics, and regulatory function of Notch signaling pathway and its roles in autoimmune diseases. |
| |
| Keywords: | autoimmune diseases Notch signaling pathway regulatory mechanism |
|
| 点击此处可从《中国现代医学杂志》浏览原始摘要信息 |
| 点击此处可从《中国现代医学杂志》下载免费的PDF全文 |
