宫颈癌继发阴道炎患者的病原菌分布及其危险因素分析

［摘要］〖HTH〗目的〖HTSS〗探讨宫颈癌继发阴道炎患者的病原菌分布情况，并分析其危险因素。〖HTH〗方法〖HTSS〗回顾性分析120例宫颈癌患者的临床资料，统计阴道炎的发生率和病原菌分布情况。按是否继发阴道炎分为发生组和未发生组，比较2组可能影响宫颈癌继发阴道炎因素的构成比，并对可能的影响因素进行Logistic回归分析。〖HTH〗结果〖HTSS〗120例宫颈癌患者中继发阴道炎42例（35.00%）；继发阴道炎患者共检出72株病原菌，真菌、革兰阴性菌和革兰阳性菌的占比分别为52.78%、31.94%和15.28%，其中分别以白色假丝酵母菌、大肠埃希菌和葡萄球菌的占比最高，分别为27.78%、12.50%和8.33%。发生组年龄＞60岁、有阴道炎既往史、伴有糖尿病、手术、手术患者术后引流时间＞24 h、化疗、放疗构成比均高于未发生组，采用阴道洗剂者构成比低于未发生组，差异有统计学意义（P＜0.05）。Logistic回归分析结果显示，年龄＞60岁、有阴道炎既往史、伴有糖尿病、手术、手术患者术后引流时间＞24 h、化疗、放疗是宫颈癌继发阴道炎的危险因素，采用阴道洗剂是宫颈癌继发阴道炎的保护因素（P＜0.05）。〖HTH〗结论〖HTSS〗宫颈癌继发阴道炎的风险较高，以真菌为主要病原菌，危险因素也较多，需要针对危险因素制定防控措施，鼓励患者合理使用阴道洗剂。

Distribution of pathogenic bacteria and its risk factors in patients with cervical cancer secondary vaginitis

［Abstract］Objective〖HTSS〗To investigate the distribution of pathogenic bacteria in patients with secondary vaginosis of cervical cancer and to analyze its risk factors. 〖HTH〗〖WTHZ〗Methods〖HTSS〗The clinical data of 120 patients with cervical cancer were analyzed retrospectively. The patients with secondary vaginitis were recorded as the occurrence group, otherwise recorded as the non-occurrence group, the constituent ratio of the factors that may affect the secondary vaginitis of cervical cancer in the two groups were compared, and the possible influencing factors were analyzed by Logistic regression analysis. 〖HTH〗〖WTHZ〗Results〖HTSS〗Among the 120 patients with cervical cancer, 42(35.00%) were secondary vaginosis. A total of 72 strains of pathogenic bacteria were detected in patients with secondary vaginitis. The proportion of fungi, Gram-negative bacteria and Gram-positive bacteria were 52.78%, 31.94% and 15.28%, respectively. Among them, Candida albicans, Escherichia coli and Staphylococcus accounted for the highest proportion, which were 27.78%, 12.50% and 8.33%, respectively. The age >60 years old, past history of vaginitis, diabetes mellitus, postoperative drainage time > 24 hours, chemotherapy and radiotherapy in the occurrence group were higher than those in the non-occurrence group, and the constituent ratio of vaginal lotion was lower than that in the non-occurrence group. The difference was statistically significant(P < 0.05). The results of Logistic regression analysis showed that age >60 years old, past history of vaginosis, diabetes mellitus, postoperative drainage time >24 hours, chemotherapy and radiotherapy were the risk factors of secondary vaginitis of cervical cancer. Vaginal lotion was a protective factor for secondary vaginosis of cervical cancer(P＜0.05). 〖HTH〗〖WTHZ〗Conclusion〖HTSS〗The risk of secondary vaginitis of cervical cancer is high. Fungi is the main pathogen and there are many risk factors. It is necessary to formulate prevention and control measures according to the risk factors and encourage patients to use vaginal lotion reasonably.