Untangling the overlap between frailty and low lean mass: Data from Toulouse frailty day hospital |
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| Affiliation: | 1. Medical Department, Geriatric Unit, Azienda ULSS (Unità Locale Socio Sanitaria) 3 “Serenissima”, Dolo-Mirano District, Italy;2. School of Public Health, Brown University, Providence, RI, USA;3. Warren Alpert Medical School, Brown University, Providence, RI, USA;4. National Research Council, Neuroscience Institute, Aging Branch, Padua, Italy;5. Geriatrics Unit, Department of Geriatric Care, OrthoGeriatrics and Rehabilitation, E.O. Galliera Hospital, National Relevance and High Specialization Hospital, Genova, Italy;6. Primary Care Department, Geriatric Unit, Azienda ULSS (Unità Locale Socio Sanitaria) 3 “Serenissima”, Dolo-Mirano District, Italy;1. Institute for Medical Information Processing, Biometry and Epidemiology, Ludwig-Maximilians-Universität München, Munich, Germany;2. German Center for Vertigo and Balance Disorders, University Hospital Ludwig-Maximilians-Universität München, Munich, Germany;3. Institute of Health Economics and Health Care Management, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Neuherberg, Germany;4. Munich Center of Health Sciences, Ludwig-Maximilians-Universität München, Munich, Germany;1. Department of Nursing, University of Valencia, Valencia, Spain;2. Servicio de Cardiología, Hospital Clínico Universitario, INCLIVA, Universitat de Valencia, Valencia, Spain;3. GeroResidencias La Saleta, Valencia, Spain;1. Medical Department, Geriatric Unit, Azienda ULSS (Unità Locale Socio Sanitaria) 3 “Serenissima”, Dolo-Mirano District, Italy;2. South London and Maudsley NHS Foundation Trust, Denmark Hill, London SE5 8AZ, United Kingdom;3. Faculty of Health, Social Care and Education, Anglia Ruskin University, Bishop Hall Lane, Chelmsford CM1 1SQ, United Kingdom;4. Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King''s College London, De Crespigny Park, London SE5 8AF, United Kingdom;5. National Research Council, Neuroscience Institute, Aging Branch, Padua, Italy;6. Primary Care Department, Azienda ULSS20 Verona, Verona, Italy;7. Primary Care Department, Azienda USL Toscana Sud Est, Grosseto, Italy;8. Primary Care Department, Aziendale AAS3 Alto Friuli – Collinare – Medio Friuli, Udine, Italy;9. Research and Development Unit, Parc Sanitari Sant Joan de Déu, Fundació Sant Joan de Déu, CIBERSAM, Barcelona, Spain;10. Nutrition and Dietetics Service, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.;11. Laboratory of Nutritional Biochemistry, Research Hospital, IRCCS “S. de Bellis”, Castellana Grotte, Bari, Italy |
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| Abstract: | BackgroundThe decline in lean mass, observed in older people, has been frequently associated with frailty. This assumption has scarcely been assessed. This study explored the association between current proposed definitions of low lean mass and the Fried phenotype of frailty.MethodsCross-sectional study. Participants admitted to the Toulouse frailty day hospital, with an assessment of body composition, 70 years or older were included consecutively in the study. Low lean mass (LLM), was identified using five international operative definitions. To construct the definitions, muscle mass was assessed using Intelligent Dual Energy X-ray absorptiometry (I-DXA, LUNAR). Frailty was assessed using the Fried criteria.ResultsData from 283 participants, mean age 82 years and 71% of women were analyzed. LLM was identified between 8.5% and 39.2% of the participants according to the different definitions. Frailty was identified in 46.6% of the sample. 9.1%–48.5% of the frail older people had LLM depending on the definition. The highest association between frailty and LLM was observed with the definition proposed by the Foundation for the National Institutes of Health (FNIH) Sarcopenia Project [adjusted Odds Ratio 2.64; 95% confidence interval 1.5–4.8].ConclusionThe decline in lean mass is a component of the frailty syndrome but not universally present. Indeed, LLM and frailty were associated and partly overlapped. Future research including longitudinal studies should exploit the added value of combining LLM and frailty measures in preventing disability and other negative health outcomes. |
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| Keywords: | Frailty Fried Low lean mass Older adults |
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