| 罗格列酮对糖尿病兔心房结构重构及氧化应激的影响 |
| |
| 引用本文： | 赵辉,李广平,刘彤.罗格列酮对糖尿病兔心房结构重构及氧化应激的影响[J].中国心脏起搏与心电生理杂志,2011,25(2):146-149. |
| |
| 作者姓名： | 赵辉 李广平 刘彤 |
| |
| 作者单位： | 天津医科大学第二医院心脏科,天津,300211 |
| |
| 基金项目： | 国家自然科学基金项目，天津医科大学科学基金项目 |
| |
| 摘 要： | 目的探讨罗格列酮对四氧嘧啶诱导的糖尿病家兔心房肌结构重构及体内氧化应激水平的影响。方法应用四氧嘧啶诱导糖尿病家兔20只,将其随机分为糖尿病组和罗格列酮干预组;10只正常家兔为对照组。三组均予普通饲料喂养5周,罗格列酮干预组兔于后4周每天予口服罗格列酮4 mg,分别测定5周后一氧化氮(NO)、丙二醛(MDA)、谷胱甘肽(GSH)、超氧化物歧化酶(SOD)水平。并剪取心房肌组织行HE和MASSON染色,测定胶原容积分数。结果与对照组比较,糖尿病组的MDA水平升高,SOD水平有降低趋势;罗格列酮干预组SOD高于糖尿病组,而MDA水平低于糖尿病组(P<0.05),而与对照组无差异(P>0.05)。NO和GSH水平三组无差异。HE及MASSON染色示糖尿病组左房肌细胞较对照组排列紊乱,炎症浸润,纤维化明显,而罗格列酮干预组炎性改变及纤维化程度均减轻。结论罗格列酮对糖尿病家兔氧化应激改变及心房肌纤维化可能存在拮抗作用。
|
| 关 键 词： | 心血管病学 糖尿病 心房颤动 罗格列酮 纤维化 氧化应激 |
The effect of the thiazolidinedione-rosiglitazone on the atrial structural remodeling and oxidative stress of alloxan-induced diabetic rabbits |
| |
| ZHAO Hui,LI Guang-ping,LIU Tong.The effect of the thiazolidinedione-rosiglitazone on the atrial structural remodeling and oxidative stress of alloxan-induced diabetic rabbits[J].Chinese Journal of Cardiac Pacing and Electrophysiology,2011,25(2):146-149. |
| |
| Authors: | ZHAO Hui LI Guang-ping LIU Tong |
| |
| Institution: | ZHAO Hui,LI Guang-ping,LIU Tong.Department of Cardiology,Second Hospital of Tianjin Medical University,Tianjin 300211,China |
| |
| Abstract: | Objective To investigate the influence of rosiglitazone on the level of GSH,SOD,NO,MDA and collagen in left atrium. Methods Twenty alloxan-injected rabbit that were supposed to have hyperglycemia were devided into 2 groups with 10 rabbits for each,diabetic group(D) and diabetic rabbits receiving rosiglitazone(DR) group,ten normal rabbits were assigned as control(C) group.All animals were feed standard diet and the DR group received rosiglitazone 2mg/kg for 4 weeks.The level of SOD,MDA,NO,and GSH were measur... |
| |
| Keywords: | Cardiology Diabetes Atrial fibrillation Rosiglitazone Fibrosis Oxiditave stress |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
