胰岛素抵抗、组织纤溶酶原激活物抑制物-1与急性冠脉综合征的相关性研究 |
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引用本文: | 李韶南,李广镰,冯开薇,雷晓明. 胰岛素抵抗、组织纤溶酶原激活物抑制物-1与急性冠脉综合征的相关性研究[J]. 中国心血管病研究杂志, 2011, 9(2): 98-101 |
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作者姓名: | 李韶南 李广镰 冯开薇 雷晓明 |
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作者单位: | 广州市第一人民医院心内科,广东省,510180 |
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摘 要: | 目的 探讨胰岛素抵抗(IR)、组织纤溶酶原激活物抑制物-1(PA1-1)与急性冠脉综合征(ACS)患者冠脉病变严重程度的关系及对患者近期预后的预测价值,并分析IR与PA1-1的相关性.方法 连续收集2008年2月至2009年7月在我院心内科住院并诊断为ACS的患者165例,按胰岛素抵抗指数水平(HOMA指数)分为2组:胰岛素抵抗(IR)组(HOMA-IR>5)80例,非IR组(HOMA-IR≤5)85例.分析两组ACS患者间PAI-1水平、冠脉病变严重程度的差异,并观察PAI-1水平及IR对接受经皮冠脉内介入治疗术(PCI)的ACS患者近期预后(6个月)的影响.结果 IR组ACS患者与非IR组相比,PAI-1水平明显升高,且冠脉病变严重程度增高,组间差异有统计学意义(P<0.05或P<0.01);多因素Logistic回归分析显示,PAI-1及IR均是ACS患者近期预后的独立预测因子.结论 纤溶功能紊乱、IR与ACS患者冠脉病变的严重程度相关,PAI-1水平及IR对ACS患者的近期预后有预测价值.
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关 键 词: | 胰岛素抵抗 急性冠脉综合征 组织纤溶酶原激活物抑制物-1 |
Relationship of unsulin resistance, plasminogen activator inhibitor-1 and the severity of acute coronary syndrome |
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Affiliation: | LI Shao-nan, LI Guang-lian, FENG Kai-wei, et al. Department of Cardiology, Guangzhou First People's Hospital, Guangzhou 510180, China |
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Abstract: | Objective To investigate the relationship of Insulin resistance(IR) and Plasminogen activator inhibitor-1 (PAl-1 ) to the severity of acute coronary syndrome (ACS), and the predictive value of IR and PAl-1 to ACS patient's recent prognosis. Methods 165 ACS patients were selected and divided into two groups accord- ing to their HOMA index: IR group (HOMA-IR〉5), Non-IR group(HOMA-IR~〈5). The differences of PAI-1 and the severity of coronary artery lesions between two group were assessed. Results The level of PAl-1 and the severity of coronary artery lesions in IR group were higher than Non-IR group's, and the t-PA level was lower than Non-IR group. PAI-1 and IR were positive correlated. Both PAI-1 and IR were strong independent predictors for the prognosis of ACS patients received PCI treatment. Conclusion PAl-1 and IR correlate with the severity of coronary artery lesions in ACS patients. They may be valuable in predicting the prognosis of ACS patients. |
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Keywords: | Insulin resistance Acute coronary syndrome Plasminogen activator inhibitor-1 |
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