空腹血糖正常的高血压患者糖代谢状态检测的临床意义

目的 检测空腹血糖正常的高血压患者的糖代谢状态,为全面干预危险因素提供科学依据.方法 对46例高血压患者、40例血压正常者做口服葡萄糖耐量试验（OGTT）,并同步测定血清胰岛素浓度.结果 高血压组OGTT检出糖耐量减低和2型糖尿病的发生率分别为28.3%和8.7%,糖代谢异常发生率与血压正常组相比差异有统计学意义（P＜0.05）.高血压组和血压正常组的胰岛素抵抗指数分别为1.2±0.3和1.0±0.4,差异有统计学意义 （P＜0.01）.结论 以OGTT同步测定血清胰岛素浓度的方法来检测高血压患者的糖代谢状态,不仅可使部分2型糖尿病和糖耐量减低患者得以早期诊断,而且可初步评估患者胰岛素敏感性及胰岛素抵抗程度,具有重要临床意义.

Clinical significance of detecting the state of glucose metabolism of hypertensive patients with normal fasting glucose

Objective To detect the state of glucose metabolism of hypertensive patients with normal fasting glucose, risk factors for a comprehensive intervention to provide a scientific basis. Methods 46 patients with hypertension and 40 patients with normal blood pressure received oral glucose tolerance test （OGqq＇）, Simultane- ous determination of serum insulin concentrations. Results OGTT detected impaired glucose tolerance and type 2 diabetes incidence rates were 28.3% and 8.7%, compared with the control group were significantly different （P〈 0.05 ）. HOMA-IR in hypertension group and control group were 1.2±0.3 and 1.0±0.4, there was a significant dif- ference （P〈0.01）. Conclusion Detecting the state of glucose metabolism of hypertensive patients with OGTT and simultaneous determinationing of serum insulin concentrations, not only may help early diagnosis type 2 diabetes incidence and impaired glucose tolerance, but also help to preliminary evluate insulin sensitivity and insulin resistance degree of hypertension patients.