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| 心房颤动患者高迁移率族蛋白1血清水平 | |
| 引用本文： | 杨新红,李艳,胡笑容,周文杰. 心房颤动患者高迁移率族蛋白1血清水平[J]. 中国心脏起搏与心电生理杂志, 2011, 25(2): 136-138 |
| 作者姓名： | 杨新红 李艳 胡笑容 周文杰 |
| 作者单位： | 1. 武汉大学人民医院检验科,湖北武汉,430060;武汉大学人民医院心内科,湖北武汉,430060 2. 武汉大学人民医院检验科,湖北武汉,430060 3. 武汉大学人民医院心内科,湖北武汉,430060 |
| 摘 要： | 目的探讨心房颤动(AF)患者血清高迁移率族蛋白1(HMGB1)水平是否升高。方法入选的55例阵发性AF患者,33例持续性AF患者,选择36例年龄和性别匹配的无AF体检者作为对照组,采用ELISA法检测血清HMGB1和高敏C反应蛋白(hs-CRP)水平。结果持续性AF患者血清HMGB1水平较对照组和阵发性AF患者显著增高(8.62±2.18 ng/m l vs 2.22±0.63 ng/m l,5.29±1.43 ng/m l,P均<0.05)。阵发性AF患者血清HMGB1水平较对照组高(P<0.05)。AF患者血清HMGB1水平与hs-CRP水平呈显著正相关(n=88,r=0.629,P<0.05)。结论 AF患者血清HMGB1水平显著上升。 |
| 关 键 词： | 心血管病学 心房颤动 高迁移率族蛋白1 炎症 |
The level of serum high mobility group box 1 protein in patients with atrial fibrillation |
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| YANG Xin-hong,LI Yan,HU Xiao-rong,ZHOU Wen-jie. The level of serum high mobility group box 1 protein in patients with atrial fibrillation[J]. Chinese Journal of Cardiac Pacing and Electrophysiology, 2011, 25(2): 136-138 | |
| Authors: | YANG Xin-hong LI Yan HU Xiao-rong ZHOU Wen-jie |
| Affiliation: | YANG Xin-honga,b,LI Yana,HU Xiao-rongb,ZHOU Wen-jieb. Renmin Hospital of Wuhan University,a Department of Clinical Laboratory Science,b Department of Cardiology,Renmin Hospital of Wuhan University,Wuhan 430060,China |
| Abstract: | Objective To investigated that whether the serum high mobility group box 1 protein （ HMGBI ） level is increased in atrial fibrillation （AF） patients. Methods A total of 88 consecutive AF patients were enrolled in this study. Thirty age- and sex-matched people without AF were considered as control group. Serum HMGB1 and high-sensitivity C-reactive protein（hs-CRP） concentration in AF patients and healthy people was measured by ELISA. Results HMGB1 level in persistent AF group （8.62 ±2.18 ng/ml） was higher than that in control group （2.22 ±0.63 ng/ml） and paroxysmal AF group （5.29 ± 1.43 ng/ml） （ both P 〈 0. 05 ）. HMGB1 level in paroxysmal AF group was higher than that in control group （P 〈 0. 05）. There was significantly positive correlation between HMGB1 and hs-CRP in AF patients （ n = 88, r =0. 629, P 〈 0. 05）. Conclusion Serum HMGB1 level is markedly increased in AF patients. |
| Keywords: | Cardiology Atrial fibrillation High mobility group box 1 protein Inflammation |
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