349例重型病毒性肝炎的临床特点及病毒标志物检测结果分析

目的了解重型病毒性肝炎住院病例的临床及病原学特点,探讨慢性肝炎重症化及其预后的关系。方法采用回顾性调查方法,对349例重型病毒性肝炎的临床特点及病毒标志物检测结果进行分析。结果349例重型病毒性肝炎患者中,发生于急性肝炎的28例,发生于慢性肝炎有明确肝病史和无明确肝病史的分别为245例和76例;引起重型肝炎的病毒中以HBV单一或重叠感染率最高,占82.2%(287/349),6例(1.72%)未能确定病原,未发现单一HAV、HDV和HGV感染者,HBV重叠HEV感染者病死率为65.2%(15/23),HEV重叠其他肝炎病毒感染者的病死率为60%(18/30),均比单一HBV或单一HEV感染者高(P<0.01和P<0.05)。结论重型肝炎仍以HBV感染为主,HBV和HEV重叠感染可以加重病情、病死率高。

The clinical characteristics and virus marker detection of 349 inpatients with severe viral hepatitis

Objective To investigate the clinical and etiologic characteristics in inpatients with severe viral hepatitis,and to explore the relation between the deterioration and prognosis of chronic viral hepatitis.Methods A total of 349 inpatients with severe viral hepatitis were reviewed retrospectively.Results In all inpatients,28 cases,245 cases and 76 cases were classified into modes of acute onset,definitely chronic onset and indefinitely chronic onset,respectively.The infected or super infected rates of HBV were 82.2%(287 cases),6 cases were not detected certain hepatitis virus.There was no case infected HAV,HDV or HGV single.The rate of death in 23 cases infected HBV combination with HEV was 65.2%(15 cases),and that in 30 cased infected HEV combination with other hepatitis virus was 60%(18 cases),which were significant higher than those infected HBV or HBV single(P<0.05).Conclusion HBV was the most common hepatitis virus in the inpatient with severe viral hepatitis.The inpatients with super infection of HBV and HEV were severe and their death rate was high.