| 男性不育患者Y染色体的AZF基因微缺失分析 |
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| 引用本文： | 陆雪,封江彬,贾金铭,刘青杰.男性不育患者Y染色体的AZF基因微缺失分析[J].中国优生与遗传杂志,2006,14(12):56-57. |
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| 作者姓名： | 陆雪 封江彬 贾金铭 刘青杰 |
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| 作者单位： | 1. 中国疾病预防控制中心辐射防护与核安全医学所,100088
2. 中国中医研究院广安门医院,100053 |
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| 基金项目： | 国家自然科学基金;北京市自然科学基金 |
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| 摘 要： | 目的探索男性不育患者Y染色体AZF基因微缺失的发生情况，为男性不育的临床诊断和治疗提供科学依据。方法应用PCR方法对36例无精或严重少精患者AZF基因的SY84、SY127和SY254进行检测分析。结果在36例患者中发现16例发生AZF基因的微缺失，均为三个基因区段不同组合的缺失。其中涉及AZFa或AZFb缺失的各8例，涉及AZFc缺失的有14例。结论AZF基因的微缺失与某些男性不育密切相关。AZFc缺失可能是男性不育中无精子、严重少精子的主要病因之一。
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| 关 键 词： | 男性不育 AZF基因 微缺失 |
| 文章编号： | 1006-9534（2006）12-0056-02 |
| 收稿时间： | 2006-09-11 |
| 修稿时间： | 2006年9月11日 |
Analysis of AZF gene microdeletion in Y chromosome for males with infertility |
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| LU Xue,FENG Jiang-bin,JIA Jin-ming,LIU Qing-Jie.Analysis of AZF gene microdeletion in Y chromosome for males with infertility[J].Chinese Journal of Birth Health & Heredity,2006,14(12):56-57. |
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| Authors: | LU Xue FENG Jiang-bin JIA Jin-ming LIU Qing-Jie |
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| Institution: | 1. National Institute for Radiological Protection, China CDC, Beijing 100088, P. R. China 2. Guang An Men Hospital, China Academy of Chinese Medical Sciences, Beijing, 100053, P. R. China |
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| Abstract: | Objective: Try to explore the AZF gene microdeletion in Y chromosome in males with infertility,in order to show the scientific evidence for diagnosis and treatment of male infertility.Methods: SY84,SY127 and SY254 in AZF gene were analyzed with PCR in 36 cases of azoospermia or severe oligozoospermia.Results: There were 16 cases with AZF gene microdeletion,which were combined deletions in AZFa,and/or AZFb,and/or AZFc.In these 16 cases,both 8 cases were detected deletions in AZFa and/or AZFb,and there were 14 cases with AZFc deletion.Conclusion: The microdeletion of AZF closely associated with some portions of male infertility.AZFc deletion could be one major cause of male infertility,including azoospermia and severe oligozoospermia. |
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| Keywords: | Male infertility AZF gene Microdeletion |
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