重度子痫前期孕妇血浆蛋白变化与围产儿结局关系的研究

目的:通过比较重度子痫前期孕妇血浆蛋白的变化对围生儿结局的影响,探讨临床对重度子痫前期孕妇诊治及改善围生儿结局的方法。方法:选取50例重度子痫前期孕妇及其新生儿为病例组,50例正常妊娠孕妇及新生儿为对照组,两组均已排除慢性肝肾疾病患者。分别测空腹血浆蛋白含量,并将病例组分为低蛋白血症组和非低蛋白血症组,回顾性分析病例组和对照组两组间及病例组内血浆蛋白的差异及对围生儿结局(终止妊娠的孕周及新生儿体重)的影响。结果:病例组血浆总蛋白(TP)、白蛋白(Alb)含量、终止妊娠的孕周及新生儿体重均明显低于对照组(P0.05),而两组间球蛋白(GT)无明显差异。病例组内低蛋白血症组(A组)与非低蛋白血症组(B组)间终止妊娠孕周差异无统计学意义,但新生儿出生体重、Apgar评分均低于后者,且围生儿死亡率亦较高,差异有统计学意义。结论:终止妊娠的孕周是围生儿预后是否良好的重要参数,重度子痫前期孕妇组血浆蛋白含量越低、围生儿的体重越小、Apgar评分越低预后越差,死亡率越高,提示重度子痫前期孕妇血浆蛋白的变化可作为预测围生儿结局的指标,维持母体血浆白蛋白水平有利于改善围生儿结局。

Study on relationship between changes of plasma protein in pregnant women with severe preeclampsia and perinatal Outcomes

Objective:To explore the measures to diagnose and treat pregnant women with severe preeclampsia and improve perinatal outcomes by comparing the effect of plasma protein in pregnant women with severe preeclampsia on perinatal outcomes.Methods:50 pregnant women with severe preeclampsia and neonates were selected as case group,and 50 normal pregnant women and neonates were selected as control group,the cases with chronic liver and renal diseases were excluded.The level of fasting plasma protein in the two grou...