| 薤白中两种新甾体皂甙成分 |
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| 引用本文： | 彭军鹏,吴雁,姚新生,奥山徹,成井孝雄. 薤白中两种新甾体皂甙成分[J]. 药学学报, 1992, 27(12): 918-922 |
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| 作者姓名： | 彭军鹏 吴雁 姚新生 奥山徹 成井孝雄 |
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| 作者单位： | 沈阳药学院植物化学教研室,沈阳110015;*日本明治药科大学生药学植物化学教研室,东京154 |
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| 摘 要： | 从中药薤白(Allium macrostemon Bunge)鳞茎中分得两种流的甾体皂甙,薤白甙甲(macrostemonoside A,1)和薤白甙丁(macrostemonoside D,2),通过光谱(IR,MS,1HNMR,13CNMR,1H-1H COSY和NOESY等)分析和衍生化研究,分别确定为:tigogenin-3-O-β-D-glucopyranosyl(1→2)[β-D-glucopyranosyl(1→3)]-β-D-glucopyranosyl(1→4)-β-D-galactopyranoside(1)和tigotenin-3-O-β-D-glucopyranosyl(1→2)[β-D-glucopyranosyl(1→3)(6-O-acetyl-β-D-glucopyranosyl)](1→4)-β-D-galactopyranoside(2)。
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| 关 键 词： | 薤白 甾体皂甙 薤白甙甲 薤白甙丁 |
| 收稿时间： | 1991-12-23 |
TWO NEW STEROIDAL SAPONINS FROM ALLIUM MACROSTEMON |
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| JP Peng,Y Wu,XS Yao,T Okuyama,T Narui. TWO NEW STEROIDAL SAPONINS FROM ALLIUM MACROSTEMON[J]. Acta pharmaceutica Sinica, 1992, 27(12): 918-922 |
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| Authors: | JP Peng Y Wu XS Yao T Okuyama T Narui |
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| Affiliation: | Department of Phytochemistry, Shenyang College of Pharmacy. |
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| Abstract: | Two new steroidal saponins, macrostemonoside A and D, were isolated from the bulbs of Allium macrostemon Bung (Chinese name as Xie bai), a Traditional Chinese Medicine used for the treatment of myocardial infarction. Their structures were established as tigogenin-3-O-beta-D-glucopyranosyl(1-->2) [beta-D-glucopyranosyl(1-->3)1]-beta-D-glucopyranosyl(1-->4)-beta-D- galactopyranoside (1) and tigogenin-3-O-beta-D-glucopyranosyl(1-->2)[beta-D-glucopyranosyl (1-->3)(6-O-acetyl-beta-D-glucopyranosyl)] (1-->4)-beta-D-galactopyranoside (2) by spectral and chemical evidences. 1 showed remarkable inhibitory effect on rabbit platelet aggregation induced by ADP in vitro (IC50 = 0.065 mmol). |
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| Keywords: | Steroidal saponin Macrostemonoside A Macrostemonoside D Allium macrostemon |
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