Neonatal Alloimmune Thrombocytopenia in Taiwan Due to an Antibody against a Labile Component of HPA-3a (Bak) |
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| Authors: | Marie Lin MD Shiow-Hua Shieh Der-Cherng Liang Ting-Fan Yang and Yoichi Shibata |
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| Affiliation: | Immunohematology Reference Laboratory, Mackay Memorial Hospital, Taipei, Taiwan;Department of Pediatrics, Mackay Memorial Hospital, Taipei, Taiwan;Department of Transfusion Medicine and Immunohematology, Tokyo University, Tokyo, Japan |
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| Abstract: | We report on two siblings who developed severe neonatal alloimmune thrombocytopenia (NAIT) due to an alloantibody against a labile component or components of the HPA-3a (Baka) antigen. The antibody reacted only with fresh, unfixed platelets by the solid-phase red cell adherence test, immunofluorescence test and mixed passive haemagglutination test. In the latter method, weakly fixed platelets also gave a weak positive reaction. Monoclonal-antibody-specific immobilization of platelet antigens and immunoblotting tests gave negative results. Our findings may possibly help to explain why in some cases of NAIT no platelet-specific antibody is demonstrable in tests with fixed or solubilized platelets. |
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