| 免疫复合物型肾小球肾炎发病机制动物实验研究 |
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| 引用本文： | 王文余,钟长恩.免疫复合物型肾小球肾炎发病机制动物实验研究[J].哈尔滨医科大学学报,1996,30(5):414-417. |
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| 作者姓名： | 王文余 钟长恩 |
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| 作者单位： | [1]免疫学教研室 [2]保健科 |
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| 摘 要： | 本文按Ｄｉｘｏｎ方法制造血清病型肾小球肾炎动物模型，进而研究发病机制，模型ＡＥＳＳＲ血清ＣＩＣ水平明显高于正常值；ＣＭＳＣ水平明显低于正常值。ｓＩＬ－２Ｒ，ＩＬ－８，ＩＦＮ，ＴＮＦ和ＩＬ－２水平平均明显高于正常值。ＣＩＣ与ＣＭＳＣ呈高度负相关，ｒ＝－０．９４３。
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| 关 键 词： | 肾小球肾炎 免疫复合物 ICGN 发病机制 |
Animal Experimental Study of Pathogenesis of ICGN |
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| Wang Wenyu,et al.Animal Experimental Study of Pathogenesis of ICGN[J].Journal of Harbin Medical University,1996,30(5):414-417. |
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| Authors: | Wang Wenyu |
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| Institution: | Department of Immunology |
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| Abstract: | Pathogenesis of ICGN was studied by AESSR.The experimental results indicated that the levels of serum CIC was increased significantly in model group;while CMSC was decreased markedly.The levels of sIL-2R,IL-2,IL-8,IFN and TNF were all higher in model group than those in normal group.A highly negative correlation was present between CIC and CMSC,but a highly positive correlation was present between CIC and IL-8.The results showed that CIC was precipitated in kidney and led to ICGN when CIC was greatly formed and CMSC was decreased and cytokines was disordered. |
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| Keywords: | AESSR CIC CMSC CKs |
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