| 锌对铅亚慢性暴露小鼠脑铅含量的影响 |
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| 引用本文： | 吴斐,叶雯婧,王瑜玥,连双庆,沈晓华,阮国洪.锌对铅亚慢性暴露小鼠脑铅含量的影响[J].海峡预防医学杂志,2009,15(1):4-5. |
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| 作者姓名： | 吴斐 叶雯婧 王瑜玥 连双庆 沈晓华 阮国洪 |
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| 作者单位： | 福建医科大学公共卫生学院,福州,350004 |
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| 基金项目： | 福建省大学生创新性实验计划项目(项目编号:C07007) |
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| 摘 要： | 目的]研究微量元素锌对铅亚慢性暴露小鼠脑铅水平的影响,探索能拮抗铅毒性的锌剂量。方法]健康昆明种小鼠随机分成6组。空白对照组灌胃蒸馏水;铅染毒组灌胃0.8 mg/10 g体重醋酸铅溶液;锌对照组灌胃高剂量醋酸锌溶液;加锌实验组分别灌胃3个剂量（低、中、高）的醋酸锌及0.8 mg/10 g体重的醋酸铅混合溶液。每3天灌胃1次,观察小鼠体重变化及死亡情况,受试3个月后处死,用石墨炉原子吸收光谱法测定小鼠的脑铅含量。结果]各剂量锌实验组小鼠的脑铅含量低于铅染毒组,与空白对照组类似,且各锌实验组间小鼠脑铅含量类似。结论]低、中、高剂量锌均能降低小鼠脑铅含量,锌可以拮抗铅在小鼠脑部的残留,低剂量锌可以拮抗铅的毒性。
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| 关 键 词： | 铅中毒 小鼠 锌 原子吸收光谱法 微量元素 毒理学 |
Effects of Zinc on Lead Content of Brain in Mice with Lead Sub-Chronic Ex-posure |
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| WU Fei,YE Wen-jing,WANG Yu-yue,et al..Effects of Zinc on Lead Content of Brain in Mice with Lead Sub-Chronic Ex-posure[J].Strait Journal of Preventive Medicine,2009,15(1):4-5. |
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| Authors: | WU Fei YE Wen-jing WANG Yu-yue |
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| Institution: | Public Health Department of Fujian Medical University;Fuzhou 350004;China |
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| Abstract: | Objective] To study the effect of zinc on the lead content of brain in lead sub-chronic exposed mice,and to explore the antagonistic dose of zinc.Methods ] Healthy Kunzea mice were divided randomly into 6 groups.The blank group,administrated with the distilled water;The lead poisoning group,administrated with 0.8 mg/10 g lead acetate water solution;The control group with high dose zinc were given high dose zinc acetate water solution;Zinc experiment groups were administrated with 0.8 mg/10 g lead acetate ... |
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| Keywords: | Lead Poisoning Mice Zinc Atomic Absorption Spectrometry Trace Element Toxicology |
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