淫羊藿甙扩血管作用机制的研究

本实验以离体兔胸主动脉条为标本，对淫羊藿甙（ＥＩ）扩血管作用的机制进行了探讨。ＥＩ２０，４０ｍｇ·Ｌ－１对ＮＥ、ＫＣｌ及ＣａＣｌ２收缩兔主动脉条的量效曲线呈非竞争性拮抗作用；ＥＩ３０ｇ·Ｌ－１能明显抑制ＮＥ诱导的兔主动脉条依赖于细胞外钙的收缩反应，对依赖于细胞内钙的收缩反应没有影响；ＥＩ３０ｇ·Ｌ－１松驰主动脉条的作用与阻断α受体或激动β受体无关。提示ＥＩ的扩血管作用机制可能与其对钙通道的阻滞作用有关。

Vasodilating mechanism of epimedium icariine

The epimedium icariine(EI) was isolated from the stem and leaves of epimedium brevicornum Maxim,and the vasodilating mechanism of EI was studied on the isolated aortic strips of rabbits.EI(20,40 mg·L-1) could non-competitively antagonize the dose-response curves of norepinephrine(NE),potassium chloride and calcium chloride.At the concentration of 30 mg·L-1,EI significantly inhibited the extracellular Ca2+-dependent contraction of aortic strips induced by NE,however,it didn't inhibit the intracellular Ca2+-dependent contraction of aortic strips induced by NE.EI(30 mg·L-1) pro duced neither α-adrenoceptic stimulating nor β-a drenoceptic blocking effects.These results indicated that the vasodilating mechanism of EI might have associated with its blocking calcium channels.