4－甲氧基－2－巯基－N－氧化吡啶钠的抗肿瘤及免疫抑制作用

４－个甲氧基－２－巯基－Ｎ－氧化吡啶钠（４－甲氧基巯氧吡啶钠，ＳｏｄｉｕｍＭｅｔｈｏｘｙｐｙｒｉｄｉｎｅｔｈｉｏｎｅ，ＳＭＰＴ）在试管内０．０１ｍｇ·Ｌ－１可抑制多种传代人癌细胞林，抑制细胞有丝分裂和损害细胞膜相结构，单用对动物移植性肿瘤无效，但明显增强氟脲嘧啶对小鼠Ｓ１８０的抑癌作用。使胸腺和脾脏重量明显减轻，抑制ＳＲＢＣ诱导的小鼠血清溶血素反应，抑制ＤＮＣＢ诱导的豚鼠皮肤迟发型超敏反应，抑制ＰＨＡ诱导的大鼠３Ｈ－ＴｄＲ参入的淋巴细胞转化。与２－巯基－Ｎ－氧化吡啶钠（巯氧吡啶钠，ＳｏｄｉｕｍＰｙｒｉｄｉｎｅｔｈｉｏｎｅ．ＳＰＴ）比较，小鼠ＬＤ５０（ｉｐ）增大，而试管内抑瘤的ＩＣ５０相近。

Studies on antitumor and immunosuppression effects of sodium 4-methoxypyridinethione

Sodium 4-methoxypyridinethione(SMPT),in vitro,possesses a significant inhibitory effect on human tumor cell strains,such as Hela,CNE-2 and Raji cell strain.In vivo,it has not inhibitory effect on the transplanted tumors,such as S180,LLC and EC,but significantly enhance the inhibitory effects of 5-Fu on S180.SMPT markedly decreases the weight of spleen and thymus,suppresses the serum hemolysins reaction induced by SRBC in mice and skin delayed type hypersensitivity reaction induced by DNCB in guineapigs.It also inhibits lyphocyte transformation induced by PHA.All these effects are shown the more the dose,the better the effect.Experiments show that SMPT is a antitumor and immuno-inhibitory compound.Compared with sodium pyridinethion(SPT),SMPT has higher LD50 in mice,However,IC50 of both SPT and SMPT has no Significant difference,in vitro.