| 海马内微量注射褪黑素的免疫调节作用 |
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| 引用本文： | 李俊,徐叔云.海马内微量注射褪黑素的免疫调节作用[J].中国药理学通报,1996,12(3):241-243. |
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| 作者姓名： | 李俊 徐叔云 |
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| 作者单位： | 安徽医科大学临床药理研究所 |
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| 摘 要： | 研究褪黑素（ＭＴ）经海马对大鼠免疫系统的影响。微量注射ＭＴ１μｇ至双侧海马，可显著地增强脾淋巴细胞ＣｏｎＡ诱导的增殖反应，其量效曲线呈钟罩形。连续３ｄ注射ＭＴ，能明显提高脾细胞产生ＩＬ－２和腹腔巨噬细胞产生ＩＬ－１，还能增强ＮＫ细胞活性。提示，ＭＴ能通过海马调节免疫功能。
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| 关 键 词： | 褪黑素 海马 淋巴细胞增殖反应 白介素1 白介素2 NK细胞 |
Immunomodulatory effects of melatonin microinjected into hippocampus in rats |
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| LI Jun,XU Shu-Yun.Immunomodulatory effects of melatonin microinjected into hippocampus in rats[J].Chinese Pharmacological Bulletin,1996,12(3):241-243. |
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| Authors: | LI Jun XU Shu-Yun |
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| Abstract: | Immunomodulatory effects of melatonin microinjected into hippocampus were studied. The results showed that splenocyte proliferative responses to ConA were enhanced significantly after melatonin(0.25～2μg) microinjected into bilateral hippocampus.Dose-response curve of melationin on the splenocyte proliferation was bell-shaped.In rats with melatonin(1μg) microinjected into their hippocampus, enhanced IL-2,elevated activity of nature kill cells and promoted IL-1 were observed. The results suggest that melatonin might modulate immunologic functions via hippocampus. |
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| Keywords: | melatonin hippocampus lymphocyte proliferation interleukin-1 interleukin2 natural killer cells |
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