| 甘草次酸钠对培养乳鼠心肌细胞损伤的保护作用 |
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| 引用本文： | 朱晓卫. 甘草次酸钠对培养乳鼠心肌细胞损伤的保护作用[J]. 中国药理学通报, 1996, 12(1): 74-76 |
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| 作者姓名： | 朱晓卫 |
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| 作者单位： | 兰州医学院药理学教研室 |
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| 摘 要： | 观察甘草次酸钠（ＳＧＡ）对培养乳鼠心肌细胞损伤的保护作用。结果：ＳＧＡ０．１０、０．２０和０．４０ｍｍｏｌ·Ｌ－１能减少缺糖缺氧６和９ｈ心肌细胞乳酸脱氢酶（ＬＤＨ）的释放；ＳＧＡ０．１０，０．２０和０．４０ｍｍｏｌ·－１对缺氧再给氧损伤６、９ｈ的心肌细胞有相似的保护作用；ＳＧＡ０．１０、０．２０和０·４０ｍｍｏｌ·Ｌ－１亦可减少氯丙嗪和黄嘌呤－黄嘌呤氧化酶损伤６，９ｈ及丝裂霉素Ｃ损伤２４ｈ心肌细胞ＬＤＨ的外漏。
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| 关 键 词： | 甘草次酸；心肌；细胞；损伤；乳酸脱氢酶 |
Protective effect of sodium glycyrrhetinic acid on injured myocardial cells from neonate rats |
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| ZHU Xiao-Wei. Protective effect of sodium glycyrrhetinic acid on injured myocardial cells from neonate rats[J]. Chinese Pharmacological Bulletin, 1996, 12(1): 74-76 |
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| Authors: | ZHU Xiao-Wei |
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| Abstract: | The protective effect of sodium glycyrrhetinic acid(SGA) on injured myocardial cells from neonate rats was investigated.SGA 0.1, 0.2 and 0.4 mmol·L-1 reduced the release of lactate dehydrogenase(LDH) from myocardial cells injured by deprivation of oxygen and glucose at 6 h or 9 h.So did SGA 0.1, 0.2 and 0.4 mmol·L-1 in myocardial cells injured by reoxygenation after anoxia at 6 or 9 h. The chlorpromazine-demaged and xathine-xanthineodaseinjured myocardial cells could also be protected by treating with 0.1,0.2 or 0.4 mmol·L-1 at 6 or 9 h. The same results were found in myocardial cells injured by mitomycine C at 24 h. |
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| Keywords: | glycyrrhetinic acid myocardium cells injury lactate dehydrogenase |
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