| 心肌肥厚大鼠免疫功能的变化及人参皂甙的调节作用 |
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| 引用本文： | 杜力军,邢善田.心肌肥厚大鼠免疫功能的变化及人参皂甙的调节作用[J].中国药理学通报,1996,12(1):84-86. |
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| 作者姓名： | 杜力军 邢善田 |
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| 作者单位： | 北京中国医学科学院，北京中国协和医科大学药用植物研究所，北京军事医学科学院毒物药物研究所 |
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| 摘 要： | 以狭窄腹主动脉方法所致大鼠心肌肥厚模型显示，在大鼠尾动脉血压升高，左心室壁增厚的同时，出现胸腺脾Ｔ细胞增殖能力降低，ＩＬ－２分泌量也明显下降，人参皂甙（５０ｍｇ·ｋｇ－１·ｄ－１，ｓｃ）在缓解血压增高的同时，能部分地升高其免疫水平，提示该药对由于心肌肥厚所出现的免疫抑制现象具有一定的调节作用。
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| 关 键 词： | 心肌肥厚 免疫 人参皂甙 大鼠 |
Immunity in myocardiac hypertrophy rat and effect of total saponins of panax ginsengin vivo and in vitro |
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| DU Li-Jun,XING Shan-Tian,RU Xiang-Bin.Immunity in myocardiac hypertrophy rat and effect of total saponins of panax ginsengin vivo and in vitro[J].Chinese Pharmacological Bulletin,1996,12(1):84-86. |
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| Authors: | DU Li-Jun XING Shan-Tian RU Xiang-Bin |
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| Abstract: | The model of rat myocardiac hyPertrophy through stricture on abdominal aorta partly by operation showed that proliferation of T cell in thymus and spleen decreased and IL-2secretion reduced markedly when rat blood pressure increased and the wall of left ventricular thickened. Total saponins of panax ginseng (TSPG 50 mg·kg-1·d-1,sc) could harmanize the higher blood presure and increase the level of immunity, suggesting TSPG may be used to strengthen the heart function as well as immunity. |
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| Keywords: | myocardiac hypertrophy immunity total saponins of panax ginseng rat |
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