汉防己甲素与秋水仙碱抗肝纤维化作用的比较

用ＣＣｌ４造成大鼠肝纤维化模型，用汉防己甲素进行抗肝纤维化治疗，并与传统抗肝纤维化药物秋水仙碱进行比较。结果显示，汉防己甲素对血清Ⅲ型前胶原与透明质酸、肝内炎症、肝胶原沉积、储脂细胞等均有明显抑制作用，与秋水仙碱作用接近，甚至在某些方面优于秋水仙碱。提示汉防己甲素可能具有治疗肝纤维化作用。

Comparative study of antifibrotic effects of tetrandrine and colchicine

Tetrandrine was used to treat liver fibrosis induced by CCl4 in rats,and its action was compared with colchicine.The results showed that serum levels of type Ⅲ procollagen(PCⅢ) and hyaluronic acid(HA) were decreased.After the treatment,inflammation,deposition of collagen,and fat-storing cells in the liver were inhibited significantly,which were close to or even superior to colchicine in some actions.It is suggested that tetrandrine is effective in the therapy of liver fibrosis.