| 黄芪多糖抗氧化损伤作用的研究 |
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| 引用本文： | 孙成文,钟国赣.黄芪多糖抗氧化损伤作用的研究[J].中国药理学通报,1996,12(2):161-163. |
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| 作者姓名： | 孙成文 钟国赣 |
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| 作者单位： | 白求恩医科大学生理中心实验室(孙成文，江岩)，白求恩医科大学生理教研室(钟国赣，战术)，白求恩医科大学有机化学教研室!长春130021(卫永弟，安占元) |
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| 摘 要： | 在培养大鼠心肌细胞的培养基中加入黄嘌呤及黄嘌呤氧化酶可使心肌细胞产生氧化损伤,表现为动作电位幅值(APA)、超射(OS)、最大舒张电位(MDP)、阈电位(TP)、最大除极速度(V_(max))减小,自发发放频率(SDF)增大.向培养基中加入200mg·L~(-1)黄芪多糖可阻止黄嘌呤及黄嘌呤氧化酶的氧化损伤作用.用黄嘌呤及黄嘌呤氧化酶造成Wistar大鼠自由基损伤,使离体心功能指标显著下降,100mg·kg~(-1)·d~(-1)黄芪多糖可使致损心脏的各项指标一致向正常方向转化.因此黄芪多糖对培养的心肌细胞和离体心脏均有抗自由基损伤作用.
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| 关 键 词： | 黄芪多糖 心肌细胞 动作电位 离体工作心脏 自由基 |
Study on antioxidant effect of Astragalus polysaccharide |
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| SUN Cheng-Wen,ZHONG Guo-Gan,ZHAN Shu et al.Study on antioxidant effect of Astragalus polysaccharide[J].Chinese Pharmacological Bulletin,1996,12(2):161-163. |
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| Authors: | SUN Cheng-Wen ZHONG Guo-Gan ZHAN Shu |
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| Abstract: | Xanthine-Xanthine oxidase ( X-XOD) added to the culture medium of cultured cardiac cells in rats may damage cell membrane. Electrophysiological findings indicated that APA, MDP, OS,Vmax, were decreased and the SDF was increased. Astragalus polysaccharide (APS) could protect the cells from being damaged by X-XOD. APS recoverted all the de-creased cardiac functional parameters in free-radical-damaged rats by X-XOD. APS had anti-free-radical damage action on the cultured my-ocardiocytes and the myocardial contractility of the isolated rat working heart. |
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| Keywords: | astragalus polysaccharide my-ocardiocytes action potencial isolated working heart free-radical |
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