| 雷尼替丁对体外培养乳鼠心肌细胞自发性搏动及动作电位的影响 |
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| 引用本文： | 杨育红,王维信.雷尼替丁对体外培养乳鼠心肌细胞自发性搏动及动作电位的影响[J].中国药理学通报,1996,12(2):164-167. |
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| 作者姓名： | 杨育红 王维信 |
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| 作者单位： | 锦州医学院药理教研室!锦州121001 |
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| 摘 要： | 本实验以培养大白鼠乳鼠心肌细胞为模型,观察了雷尼替丁对培养心肌细胞自发性搏动频率及动作电位的影响.结果表明:雷尼替丁1～100μmol·L~(-1)对正常心肌细胞搏动频率影响不大,但100μmol·L~(-1)可以阻止组胺10μmol·L~(-1)引起的心肌细胞搏动频率的增快,而对异丙肾上腺素2μmol·L~(-1)引起的心肌细胞搏动频率无明显抑制作用.组胺10μmol·L~(-1)可以使心肌细胞动作电位的APA,V_(max)及OS明显增高,APD_(50)和APD_(90)明显延长,SCL明显缩短.雷尼替丁100μmol·L~(-1)可以抑制此反应.以上结果,说明雷尼替丁对组胺增高所致的心律失常可能有防治作用.
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| 关 键 词： | 培养细胞 心肌 组胺 雷尼替丁 异丙肾上腺素 自发性搏动 动作电位 |
Effects of ranitidine on spontaneous beating and action potential of cultured mycardial cells of neonatal rats |
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| YANG Yu-Hong,WANG Wei-Xin.Effects of ranitidine on spontaneous beating and action potential of cultured mycardial cells of neonatal rats[J].Chinese Pharmacological Bulletin,1996,12(2):164-167. |
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| Authors: | YANG Yu-Hong WANG Wei-Xin |
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| Abstract: | The effects of ranitidine (Ran) on cultured myocardial cells of neonatal rats were observed. Ran 100 μmol·L-1 took no effect on spontaneous beating rates of cultured myocardial cells, but it decreased the beating rates increased by histamine 10 μmol·L-1 and did not inhibit the beating rates increased by isoprenaline 2μmol·L-1. Histamine 10μmol·L-1 increased the amplitude, maximal rate of rise and pro-longed action potential duration at 50% (APD50) and 90% (APD90) repolarization. The effect was abolished by Ran 100μmol·L-1. The results suggested that Ran may possess antiarrhythmic action induced by histamine's increase. |
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| Keywords: | cultured cells myocardium histamine ranitide spontaneous beating iso-prenaline action potentials |
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