卡托普利对高血压大鼠血小板内游离钙和血小板功能的影响

本文建立二肾一夹型肾血管性高血压大鼠(2KIC-RHR)动物模型,观察大鼠在高血压稳定期血小板胞浆内游离钙浓度([Ca~(2+)]_i)及血小板聚集率(PAg)的变化并研究了ACEI—卡托普利对高血压大鼠血小板内[Ca~（2+）]_i及血小板聚集功能的影响.结果发现:高血压大鼠血小板内[Ca~（2+）]_i及血小板聚集率均显著升高(P<0.01),卡托普利显著降低血压同时血小板内[Ca~（2+）]_i、血小板聚集率也明显减小(P<0.01).提示:2KIC—RHR在高血压稳定期存在血小板内钙代谢异常和血小板功能的改变,血小板活性的降低可能参与卡托普利的降压作用.

The effect of Captopril on platelets cytosolic free calcium and platelets aggregation in renovascular hypertensive rats

To evaluate effects and mechanism of Captopril on BP of 2 -kidney, 1 -clip reno-vascular hypertensive rats ( 2K1C - RHR ), Platelets cytosolic free calcium, concentration ([Ca2 ]i) and platelets aggregation (PAg) are measured. The results are as follows: [Ca2 ]; and PAg increase significantly (P<0. 01); Captopril has obvious antihypertension, with [Ca2 ]i and PAg decreasing markedly (P<0.01).These indicate that there is abnormality of intracellular calcium and platelets activity during sustain period of hypertension in the 2K1C -RHR. Moreover, the antihypertension of Captopril may attribute to regression of platelets activity.