Oncogenic BRAF induces melanoma cell invasion by downregulating the cGMP-specific phosphodiesterase PDE5A期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Oncogenic BRAF induces melanoma cell invasion by downregulating the cGMP-specific phosphodiesterase PDE5A

Authors:	Arozarena Imanol Sanchez-Laorden Berta Packer Leisl Hidalgo-Carcedo Cristina Hayward Robert Viros Amaya Sahai Erik Marais Richard

Affiliation:	The Institute of Cancer Research, Signal Transduction Team, Section of Cell and Molecular Biology, 237 Fulham Road, London SW3 6JB, UK.

Abstract:	Download : Download high-res image (128KB) Download : Download full-size image Highlights? Oncogenic BRAF downregulates PDE5A in melanoma cells ? PDE5A downregulation or inhibition induces invasion in BRAF mutant melanoma cells ? PDE5A regulates invasion by increasing cGMP, Ca²⁺, and contractility in melanoma cells ? PDE5A loss increases short and long-term colonization of the lungs by melanoma cells

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