Review: Side effects of drug treatments for gastro-oesophageal reflux disease: current controversies |
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| Authors: | Anjan Dhar Frances Maw Helen Jane Dallal Stephen Attwood |
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| Institution: | 1. Gastroenterology, County Durham & Darlington NHS Foundation Trust, Darlington, UK ; 2. Pharmacy, County Durham and Darlington NHS Foundation Trust, Darlington, Darlington, UK ; 3. Durham University, Durham, UK |
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| Abstract: | The two main drugs used in the treatment of gastro-oesophageal reflux disease are proton pump inhibitors and histamine-2 receptor antagonists and both these agents have been implicated in a number of adverse effects, leading to considerable controversies related to their long-term use. This paper is aimed at a critical review of the published literature and the clinical significance of these reported side effects, most of which are associations rather than causal. |
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| Keywords: | acid-related diseases adverse drug reactions gastroesophageal reflux disease |
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