| WNT信号通路及其与唇腭裂发生 |
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| 引用本文： | 蔡生青(综述),王,石冰(审校). WNT信号通路及其与唇腭裂发生[J]. 国际口腔医学杂志, 2013, 0(6): 786-789 |
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| 作者姓名： | 蔡生青(综述) 王 石冰(审校) |
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| 作者单位： | 口腔疾病研究国家重点实验室 华西口腔医院唇腭裂外科(四川大学)成都 610041 |
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| 基金项目： | 国家自然科学基金资助项目 |
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| 摘 要： | WNT信号通路作为调控胚胎发生的四大信号转导途径之一，主要参与细胞的增殖、分化和极化以及程序性细胞死亡和抗程序性细胞死亡等，近年来其研究逐渐成为热点。唇腭裂作为最常见的先天性畸形，其发病机制至今尚无定论。研究显示，WNT信号通路与唇腭裂发生关系密切，本文就WNT信号通路及其与唇腭裂发生的研究进展作一综述。
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| 关 键 词： | WNT信号通路 信号转导 唇裂 腭裂 发生 |
WNT signal and its relation with cleft lip and palate |
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| Cai Shengqing , Wang Yan , Shi Bingd. WNT signal and its relation with cleft lip and palate[J]. Journal of International Stomatology, 2013, 0(6): 786-789 |
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| Authors: | Cai Shengqing Wang Yan Shi Bingd |
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| Affiliation: | Cai Shengqing, Wang Yan, Shi Bing. (State Key Laboratory of Oral Diseases, Dept. of Cleft Lip and Palate Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China) |
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| Abstract: | WNT signal is involved in embryonic development. It is mainly involved in cell proliferation, differentiation, polarization, apoptosis, and anti-apoptosis. Recently, it has become the focus of many research. Cleft lip and palate are the major congenital malformations, and their pathogenesis is unclear. The WNT signal has been shown to have a close relationship with cleft lip and palate. This review summarized the research progress of WNT signal and its relation with cleft lip and palate. |
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| Keywords: | WNT signaling signal transduction cleft lip cleft palate happen |
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