Mutagenicity of 3-nitrodibenzofuran and 3-aminodibenzofuran |
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| Authors: | Y Uno H Matsushita T Uehiro A Yasuhara M Morita |
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| Institution: | Chemistry and Physics Division, National Institute for Environmental Studies, Ibaraki, Japan. |
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| Abstract: | Mutagenicities of 3-nitrodibenzofuran and 3-aminodibenzofuran were examined using Salmonella typhimurium TA98 and TA100. Strong mutagenicity was found in both compounds. The mutagenic potency of 3-nitrodibenzofuran was approximately 3.5-fold stronger in TA98 and twice stronger in TA100 than that of benzoa]pyrene. Mutagenicity of 3-aminodibenzofuran was observed under metabolic activation and was 10 times stronger in TA98 and about 5 times stronger in TA100 than that of benzoa]pyrene. |
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