Primary central nervous system lymphoma presenting as autonomic dysfunction

Summary We describe a patient with primary central nervous system lymphoma (PCNSL) who presented with symptoms of subacute onset of dysautonomia. Autonomic testing indicated a peripheral autonomie neuropathy while magnetic resonance imaging revealed brainstem involvement. We propose that this patient's autonomie dysfunction could be the result of a paraneoplastic syndrome and PCNSL should be considered in the differential diagnosis of dysautonomia.