Thrombocytopenia: a complication of Kawasaki disease |
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| Authors: | T. Hara Y. Mizuno H. Akeda J. Fukushige K. Ueda T. Aoki H. Sunagawa S. Honda T. Hijii Y. Yamaguchi T. Hosoyamada |
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| Affiliation: | (1) Department of Paediatrics, Faculty of Medicine, Kyushu University, 3-1-1, Maidashi, Higashi-Ku, 812 Fukuoka city, Japan;(2) Fukuoka Municipal Children's Hospital, Fukuoka, Japan;(3) Fukuoka Red Cross Hospital, Fukuoka, Japan |
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| Abstract: | Thrombocytopenia was observed in 10 (2.0%) of 486 children with Kawasaki disease. In nine of the ten, the minimal paltelet count of 94000±38000 (SD)/mm3 was seen on day 6.8±2.2 (SD) of illness and the platelet counts were elevated to the normal level in 1–2 weeks. Thrombocytopenia in the nine appeared to be caused via coagulation-mediated platelet consumption, while the remaining child was diagnosed as having idiopathic thrombocytopenic purpura. One of the two who had severe coagulation-mediated thrombocytopenia of less than 50000/mm3 developed coronary aneurysms persisting over 1 year.Abbreviations APTT Activated partial thromboplastin time - ESR Erythrocyte sedimentation rate - FDP Fibrinogen/fibrin degradation products - ITP Idiopathic thrombocytopenic purpura - PT Prothrombin time - SD Standard deviation |
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| Keywords: | Kawasaki disease Thrombocytopenia Aneurysm |
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