Human leukocyte antigen in genodermatosis

ABSTRACT: Tissue typing performed on the lymphocytes of 41 Patients, including: 23 patients with ichthyosis (15 of autosomal dominant and 8 of the x-linded variety; 8 patients with tuberous sclerosis (epiloia); and 10 patients with acroder-matitis enteropathica (AEP). In adddition, tissue typing was performed for a control group of 80 healthy unrelated subjects of the same ethnic origin as the patients. A significant increase of A₂ antigen or its crossreacting antigen A₂₈ was detected among the three diseases studied. A significant increase of HLA-A₂ antigen was found in autosomal dominant ichthyosis, while the x-linked variety showed significant association with HLA-Cw2. A significant association with HLA-A₂₈ antigen was noticed in both epiloia and AEP. The suggested mechanisms of such association may be refferred to as incidental genetic linkage with mutants causing disease or deficiency.