| 组织工程皮肤与正常皮肤组织学差异的实验研究 |
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| 引用本文： | 李媛,陆伟,冀堃,刘源,董绍忠,金岩.组织工程皮肤与正常皮肤组织学差异的实验研究[J].第四军医大学学报,2009(24). |
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| 作者姓名： | 李媛 陆伟 冀堃 刘源 董绍忠 金岩 |
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| 作者单位： | 第四军医大学口腔医学院口腔组织病理学教研室;第四军医大学组织工程研发中心; |
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| 基金项目： | 国家高技术研究发展计划(863计划)组织工程皮肤重大专项(2006AA02A119); 陕西省社发攻关项目(2009K14-03) |
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| 摘 要： | 目的:研究组织工程皮肤与正常皮肤表皮层组织学的差异,并探讨其意义.方法:用组织工程方法构建人全层皮肤,以正常在体皮肤作为对照,组织学、免疫细胞化学、透射电镜观察表皮层的异同.结果:组织工程皮肤与正常皮肤在组织学上有一定差异,缺少上皮钉突,CK19在组织工程皮肤成熟期表达阴性,但CK10和pan-CK在两者表达皆为阳性,透射电镜观察上皮结构接近正常皮肤.结论:组织工程皮肤表皮层与真皮层结合不如正常皮肤紧密,可能与缺少上皮钉突有关,其表皮细胞基本分化成熟.
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| 关 键 词： | 组织工程皮肤 正常皮肤 再生 |
Experimental research of histological difference between tissue-engineered skin and normal human skin |
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| LI Yuan,LU Wei,JI Kun,LIU Yuan,DONG Shao-Zhong,JIN Yan.Experimental research of histological difference between tissue-engineered skin and normal human skin[J].Journal of the Fourth Military Medical University,2009(24). |
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| Authors: | LI Yuan LU Wei JI Kun LIU Yuan DONG Shao-Zhong JIN Yan |
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| Institution: | LI Yuan1,LU Wei1,2,JI Kun2,LIU Yuan1,DONG Shao-Zhong1,JIN Yan1,2 1Department of Oral Histopathology,School of Stomatology,2Research and Development Center for Tissue Engineering,Fourth Military Medical University,Xi'an 710033,China |
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| Abstract: | AIM:To study the differences in histology of the tissue-engineered skin and normal human skin.METHODS:The bilayer skin replacement was constructed by tissue engineering method,compared with the normal human skin by histological and immunohistochemistry methods.RESULTS:There were some differences in tissue-engineered skin and the normal skin.Epidermis rete pegs were presented only in the normal skin,CK19 was negative in the matured tissue engineered-skin,but both CK10 and pan-CK were positively expressed in ... |
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| Keywords: | tissue-engineered skin normal skin regeneration |
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