An Update on the Neurologic Applications of Botulinum Toxins |
| |
Authors: | Virgilio Gerald H Evidente Charles H Adler |
| |
Institution: | 1.Department of Neurology,Mayo Clinic Arizona,Scottsdale,USA |
| |
Abstract: | Initially used to treat strabismus in the 1970s, botulinum toxin now has more than a hundred possible medical applications.
Its utility in neurologic conditions has largely involved treating movement disorders (particularly dystonia and conditions
with muscle hyperactivity), although practically any hyperkinetic movement disorder may be relieved by botulinum toxin, including
hemifacial spasm, tremor, tics, myoclonus, and spasticity. Although initially thought to inhibit acetylcholine release only
at the neuromuscular junction, botulinum toxins are now recognized to inhibit acetylcholine release at autonomic cholinergic
nerve terminals, as well as peripheral release of neurotransmitters involved in pain regulation. Thus, their use in neurology
has been expanded to include headache and other pain syndromes, as well as hypersecretory disorders. This article highlights
some of the common neurologic conditions currently improved by botulinum toxins and reviews the scientific evidence from research
studies and clinical experience with these conditions. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|