阿魏酸乙酯对博莱霉素诱导大鼠肺纤维化的保护作用

目的：观察阿魏酸乙酯（EF）对博莱霉素诱导的大鼠肺纤维化的保护作用.方法：将60只SD大鼠,随机分为5组,对照组、模型组、3个不同EF剂量给药组.大鼠博莱霉素气管给药建立肺纤维化模型后,采用EF灌胃给药进行治疗,于第1,2周后处死动物,肺组织匀浆进行超氧化物歧化酶（SOD）活力、丙二醛（MDA）、谷胱甘肽（GSH）、肿瘤坏死因子（TNF-α）含量检测,同时对肺组织进行病理学检查,以比较不同组别肺纤维化程度.结果：与模型组相比,EF治疗组中肺组织匀浆MDA,TNF-α含量降低,而SOD活力及GSH含量显著增高,且具有一定的剂量效应关系,病理学显示EF治疗组肺纤维化程度较未治疗组明显减轻.结论：阿魏酸乙酯对博莱霉素诱导的大鼠肺纤维化具有一定的保护作用.

Protective effect of Ethyl ferulate on pulmonary fibrosis induced by bleomycin in rats

AIM：To observe protective effect of Ethyl ferulate （EF）on bleomycin induced pulmonary fibrosis of rats.METHODS：All rats were randomly divided into control group,model group and three EF groups. Various doses of EF were ig given to 36 rats for 1 or 2 weeks respectively. On week 1 and 2,the rats were killed and lungs were harvested. The lungs were homogenized for biochemical assays of SOD activity MDA,GSH and TNF-α contents. The lung tissue of rats was subjected to histopathological studies.RESULTS：Compared to model group,pulmonary fibrosis was alleviated in each EF group significantly; on 1 and 2 weeks, SOD activity, GSH content of homogenized lungs in each treated group were increased than that of model group. MDA, TNF-α contents of homogenized lungs in each group were decreased than that of model group. It also has a dose- response relationship. CONCLUSION： Ethyl ferulate has obvious protective effect for the pulmonary fibrosis induced by bleomycin in rats.