| 余甘子对胰岛素抵抗大鼠骨骼肌PKB表达和GLUT4 mRNA表达的影响 |
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| 引用本文： | 董坤,李昌炜,曲卉,赵景楠.余甘子对胰岛素抵抗大鼠骨骼肌PKB表达和GLUT4 mRNA表达的影响[J].第四军医大学学报,2009(21):2352-2355. |
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| 作者姓名： | 董坤 李昌炜 曲卉 赵景楠 |
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| 作者单位： | 西北工业大学体育部;上海体育学院体育教育训练学院;武警工程学院军事经济系;西安陆军学院军事共同教研室; |
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| 摘 要： | 目的：观察余甘子提取物对胰岛素抵抗大鼠骨骼肌PKB表达和GLUT4 mRNA表达的影响.方法：SD大鼠30只,随机分为正常对照组10只,给予基础饲料;模型组20只,给予高脂饲料.模型组大鼠给予高脂喂养6wk后,随机分为2亚组：胰岛抵抗组,继续高脂饮食;余甘子组：给予高脂饲料同时进行2mL剂量3.5g/kg余甘子提取物灌胃.干预6wk后,分别检测3组大鼠骨骼肌PKB表达和GLUT4 mRNA表达的差异.结果：高脂饮食成功诱导了胰岛素抵抗,余甘子提取物显著改善了胰岛素抵抗,胰岛素抵抗组大鼠骨骼肌PKB表达和GLUT4 mRNA表达显著低于安静对照组和余甘子组,余甘子组与安静对照组相比无显著差异.结论：余甘子提取物明显改善胰岛素抵抗,可能与其提高大鼠骨骼肌PKB表达和GLUT4 mRNA表达有关.
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| 关 键 词： | 胰岛素抵抗 余甘子提取物 骨骼肌 蛋白激酶B 葡萄糖转运蛋白4 |
Effect of phyllanthus emblica L on the expression of protein kinase B and glucose transporter4 mRNA in the skeletal muscle of insulin resistance rat |
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| DONG Kun,LI Chang-Wei,QU Hui,ZHAO Jing-NanNorthwestern Polytechnical University,Xi'an ,China,Shanghai University of Sport,Shanghai ,Engineering College of Armed Forces,Xi'an ,Xi'an Military Academy,Xi'an.Effect of phyllanthus emblica L on the expression of protein kinase B and glucose transporter4 mRNA in the skeletal muscle of insulin resistance rat[J].Journal of the Fourth Military Medical University,2009(21):2352-2355. |
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| Authors: | DONG Kun LI Chang-Wei QU Hui ZHAO Jing-NanNorthwestern Polytechnical University Xi'an China Shanghai University of Sport Shanghai Engineering College of Armed Forces Xi'an Xi'an Military Academy Xi'an |
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| Institution: | DONG Kun1,LI Chang-Wei2,QU Hui3,ZHAO Jing-Nan41Northwestern Polytechnical University,Xi'an 710072,China,2Shanghai University of Sport,Shanghai 200438,3Engineering College of Armed Forces,Xi'an 710086,4Xi'an Military Academy,Xi'an 710108 |
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| Abstract: | AIM:To observe Fructus phyllanthi's effect on protein kinase B and glucose transporter 4( GLUT4) mRNA expression in insulin resistance(IR) rats by high fat diet. METHODS:Thirty male Wistar rats were randomly divided into the control group(n=10) which was given basic diet,and the model group(n=20) which was given high fat diet.After 6 weeks,the model group was randomly divided into 2 subgroups:insulin resistant group which continued to receive high fat diet,and a Fructus Phyllanthi group which abide high fat... |
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| Keywords: | insulin resistance Fructus phyllanthi skeletal muscle protein kinase B glucose transporter 4 |
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