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Comparison of rifabutin susceptibility and rpoB mutations in multi-drug-resistant Mycobacterium tuberculosis strains by DNA sequencing and the line probe assay |
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| Authors: | Shiomi Yoshida Katsuhiro Suzuki Tomotada Iwamoto Kazunari Tsuyuguchi Motohisa Tomita Masaji Okada Mitsunori Sakatani |
| Affiliation: | (1) Clinical Research Center, National Hospital Organization, Kinki-chuo Chest Medical Center, 1180 Nagasone-cho, Sakai 591-8555, Japan;(2) Department of Clinical Microbiology, National Hospital Organization, Kinki-chuo Chest Medical Center, Sakai, Japan;(3) Department of Microbiology, Kobe Institute of Health, 4-6 Minatojima-nakamachi, Chuo-ku, Kobe 650-0046, Japan;(4) Department of Respiratory Medicine, National Hospital Organization, Kinki-chuo Chest Medical Center, 1180 Nagasone-cho, Kita-ku, Sakai 591-8555, Japan |
| Abstract: | We compared rifabutin susceptibility and rpoB mutations in 98 multi-drug-resistant strains of Mycobacterium tuberculosis (MDR-TB) by DNA sequencing and with a line probe assay using the commercially available INNO-LiPA Rif. TB kit (the LiPA). Our results indicated that rifabutin continues to remain active against MDR-TB strains harboring certain genetic alterations and also that the LiPA might be useful in identifying MDR-TB strains susceptible to rifabutin. |
| Keywords: | Tuberculosis Drug resistance Rifabutin Line probe assay |
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