脂联素与高血压病患者心肌纤维化及血管内皮功能的相关性研究

目的：观察脂联素与高血压病患者心肌纤维化及血管内皮功能的相关性,探讨脂联素对高血压心肌纤维化的影响及作用机制.方法：测定80例初发高血压病患者（高血压组）和80例健康者（对照组）的血清脂联素、血浆内皮素-1（ET-1）、血清Ⅰ型前胶原（PCⅠ）、Ⅲ型前胶原（PCⅢ）、血清一氧化氮（NO）、肱动脉血流介导的血管内皮依赖性舒张功能（FMD）等指标.结果：高血压组患者的血清PCⅠ,PCⅢ、血浆ET-1和收缩压显著高于对照组（P〈0.05）,血清脂联素、NO和FMD显著低于对照组（P〈0.05）.高血压病患者的血清脂联素与FMD（r=0.483）和NO（r=0.417）呈显著正相关;与血清PCⅢ（r=0.601）,PCⅠ（r=0.552）,ET-1（r=0.429）和收缩压（r=0.321）呈显著负相关.结论：脂联素可通过增加NO,减少ET-1的释放而改善血管内皮功能,抑制高血压心肌纤维化过程.

Correlation between adiponectin and myocardial fibrosis,vascular endothelial function in hypertensives

AIM：To investigate the correlation between adiponectin and myocardial fibrosis,vascular endothelial function and evaluate function and mechanism of adiponectin on myocardial fibrosis in hypertension. METHODS：Serum adiponectin,plasma endothelin-1 （ET-1）,procollagen typeⅠ（PCⅠ）,procollagen type Ⅲ （PCⅢ）,serum nitric oxide （NO） and flow-mediated dilation （FMD） were measured in eighty newly diagnosed hypertensives （hypertensive group） and eighty healthy persons （control group）. RESULTS：PCⅠ,PCⅢ,plasma ET-1 and systolic pressure were significantly higher than in control group （P 〈 0.05 ）, while serum adiponectin, NO and FMD were significantly lower than in control group （ P 〈 0.05 ）. Serum adiponectin levels were positively correlated with FMD （ r = 0. 483 ） and NO （ r = 0.417）, while negatively correlated with PC Ill （ r = 0. 601 ）, PC （r=0.552）,ET-1 （r=0.429） and systolic pressure （r= 0.321 ）. CONCLUSION： Adiponectin may improve vascular endothelial function and inhibit myocardial fibrosis in hypertension via increasing NO and reducing ET-1.