| 大鼠PDLLA/FK506复合神经套管模型脊髓背角c-fos的表达 |
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| 引用本文： | 曾尟枚,邬明,唐忠志,程青,王忠强. 大鼠PDLLA/FK506复合神经套管模型脊髓背角c-fos的表达[J]. 医学争鸣, 2009, 30(24): 2940-2943 |
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| 作者姓名： | 曾尟枚 邬明 唐忠志 程青 王忠强 |
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| 作者单位： | 广州军区武汉总医院急诊科,湖北,武汉,430070;广州军区武汉总医院急诊科,湖北,武汉,430070;广州军区武汉总医院急诊科,湖北,武汉,430070;广州军区武汉总医院急诊科,湖北,武汉,430070;广州军区武汉总医院急诊科,湖北,武汉,430070 |
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| 基金项目： | 湖北省卫生厅科研基金(JX2B45) |
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| 摘 要： | 目的：建立大鼠PDLLA/FK506（外消旋聚乳酸/FK506）复合套管坐骨神经再生模型,观察大鼠坐骨神经再生过程中行为学、痛阈以及脊髓背角c-fos表达的改变,研究大鼠PDLLA/FK506复合套管外周神经再生模型中神经病理痛的变化.方法：雄性Wistar大鼠40只,体质量180～200g,随机分成2组,每组20只,A组为坐骨神经损伤PDLLA/FK506套管修复组; B组为假手术组.术后27d起检测行为学、机械刺激阈值、热缩足反射时间及c-fos表达计数.结果：A组术后27d后机械痛阈和热缩足反射潜伏期与B组相差明显,有统计学意义（P〈0.05）.A组术侧L4～5脊髓背角与B组相比较,背角浅层c-fos计数增多,有统计学意义（P〈0.05）.A组组内c-fos、机械痛阈和热缩足反射潜伏期45d与27d比较均有统计学意义（P〈0.05）.结论：大鼠PDLLA/FK506复合套管外周神经再生模型中神经再生过程中诱发脊髓背角浅层c-fos表达,同时出现再生神经支配区域的神经病理痛和疼痛相关行为.
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| 关 键 词： | 周围神经 神经再生 神经病理痛 c-fos PDLLA FK506复合套管 |
C-fos expression in cornu dorsale medullae spinalis in PDLLA/FK506 compound condit peripheral nerve regeneration model in rats |
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| ZENG Xian-Mei,WU Ming,TANG Zhong-Zhi,CHENG Qing,WANG Zhong-Qiang. C-fos expression in cornu dorsale medullae spinalis in PDLLA/FK506 compound condit peripheral nerve regeneration model in rats[J]. Negative, 2009, 30(24): 2940-2943 |
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| Authors: | ZENG Xian-Mei WU Ming TANG Zhong-Zhi CHENG Qing WANG Zhong-Qiang |
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| Affiliation: | ZENG Xian-Mei,WU Ming,TANG Zhong-Zhi,CHENG Qing,WANG Zhong-Qiang Department of Emergency,Wuhan General Hospital of Guangzhou Military Area Command,Wuhan 430070,China |
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| Abstract: | AIM:By observing pain threshold and changes of c-fos expression in the dorsal horn in PDLLA/FK506 compound condit peripheral nerve regeneration model to investigate regeration nerve's neuropathic pain.METHODS:Forty male Wistar rats weighing 180-200 g were randomly divided into 2 groups:PDLLA/FK506 compound condit regeneration model group(group A) and sham-operation group(group B).The right sciatic nerve of group A underwent transection and then repaired with PDLLA/FK506 compound condit while 10 mm nerve def... |
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| Keywords: | peripheral nerve regeneration neuropathic pain c-fos PDLLA/FK506 compound |
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