Dexamethasone to prevent postextubation airway obstruction in adults: a prospective,randomized, double-blind,placebo-controlled study |
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| Authors: | Chao-Hsien Lee Ming-Jen Peng Chien-Liang Wu |
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| Affiliation: | (1) Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Mackay Memorial Hospital, No. 92, Section 2, Chung Shan North Road, Taipei City, 104, Taiwan;(2) Mackay Medicine, Nursing and Management College, No.92, Shengjing Rd, Beitou District, Taipei City, 112, Taiwan |
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| Abstract: | Introduction Prophylactic steroid therapy to reduce the occurrence of postextubation laryngeal edema is controversial. Only a limited number of prospective trials involve adults in an intensive care unit. The purpose of this study was to ascertain whether administration of multiple doses of dexamethasone to critically ill, intubated patients reduces or prevents the occurrence of postextubation airway obstruction. Another specific objective of our study was to investigate whether an after-effect (that is, a transient lingering benefit) exists 24 hours after the discontinuation of dexamethasone. |
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