临床及亚临床甲状腺功能亢进症患者骨密度的临床分析

目的：探讨临床及亚临床甲状腺功能亢进症（甲亢）患者骨密度的变化。方法：选择临床甲亢与亚临床甲亢患者各80例,按性别和年龄分亚组,男性≤50岁、男性〉50岁2个亚组;女性分绝经前和绝经后2个亚组。用骨定量CT（QCT）测定L2～4椎体的骨密度（bone mineral density,BMD）,同时测定甲状腺功能、血钙、血磷、碱性磷酸酶等指标。亚临床甲亢患者与正常对照组进行同样的检测,对结果进行组间、组内对比分析。结果：组间对比：临床甲亢组腰椎BMD显著低于对照组;亚临床甲亢组BMD与对照组比较差异无统计学意义;临床甲亢组BMD与亚临床甲亢组对比差异有统计学意义。组内对比,各组内女性绝经后腰椎BMD显著低于绝经前组;男性腰椎BMD与年龄比较差异无统计学意义。结论：临床甲亢组导致骨量丢失明显,亚临床甲亢女性绝经后组BMD减低。

Clinical analysis of the Patients Bone Mineral Density of Clinical and Subclinical Hyperthyroidism

Objective： To explore the effects of clinical and subclinical hyperthyroidism （SH）on the bone mineral density. Methods： Eighty patients with clinical hyperthyroidism and eighty patients with subclinical hyperthyroidism according sex and age, divided into subgroup. Male divided into lass than and equal to fifty and more than fifty. Female divided into before menopause and late menopause. Bone mineral density（BMD） of L2-4 were measured by QCT. At the same time. The function of hypothyroid. Calcium （Ca） and phosphorus （P） in blood,alkaline phosphatase in serum（ALP） were also measured. Clinical and subclinical hyperthyroidism have same measured as healthy control group. To contrast and analyse the result of in the group and between the group. Results： To contrast in the group. BMD of lumber of clinical hyperthyroidism were significantly lower than control group. BMD of lumber of subclinical hyperthyroidism were no significantly difference than control group. To contrast BMD of clinical hyperthyroidism and subclinical hyperthyroidism. There were difference, to contrast between the group. As Female . The BMD of lumber of late menopause were significantly lower than before menopause. As male . The BMD of lumber were no significantly difference than age. Conclusions： The group of clinical hyperthyroidism lead the bone mass lose obviously, the BMD of subclinical hyperthyroidism of female late menopause were lower.