Correlation of SARS-CoV-2 Subgenomic RNA with Antigen Detection in Nasal Midturbinate Swab Specimens |
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| Authors: | Katherine Immergluck,Mark D. Gonzalez,Jennifer K. Frediani,Joshua M. Levy,Janet Figueroa,Anna Wood,Beverly B. Rogers,Jared O’ Neal,Roger Elias-Marcellin,Allie Suessmith,Julie Sullivan,Raymond F. Schinazi,Ahmed Babiker,Anne Piantadosi,Miriam B. Vos,Greg S. Martin,Wilbur A. Lam,Jesse J. Waggoner |
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| Abstract: | Among symptomatic outpatients, subgenomic RNA of severe acute respiratory syndrome coronavirus 2 in nasal midturbinate swab specimens was concordant with antigen detection but remained detectable in 13 (82.1%) of 16 nasopharyngeal swab specimens from antigen-negative persons. Subgenomic RNA in midturbinate swab specimens might be useful for routine diagnostics to identify active virus replication. |
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| Keywords: | severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 coronavirus viruses coronavirus disease COVID-19 respiratory infections RNA subgenomic RNA nucleocapsid antigen detection nasal midturbinate nasopharyngeal swab specimens zoonoses |
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