Detection of Chlamydia in the peripheral blood cells of normal donors using in vitro culture, immunofluorescence microscopy and flow cytometry techniques |
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Authors: | Frances Cirino Wilmore C Webley Corrie West Nancy L Croteau Chester Andrzejewski and Elizabeth S Stuart |
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Institution: | (1) Department of Microbiology, University of Massachusetts, Amherst Massachusetts, 01003, USA;(2) Department of Transfusion Medicine Baystate Medical Center, Springfield, Massachusetts, 01199, USA |
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Abstract: | Background
Chlamydia trachomatis (Ct) and Chlamydia pneumoniae (Cp) are medically significant infectious agents associated with various chronic human pathologies. Nevertheless, specific roles
in disease progression or initiation are incompletely defined. Both pathogens infect established cell lines in vitro and polymerase chain reaction (PCR) has detected Chlamydia DNA in various clinical specimens as well as in normal donor peripheral blood monocytes (PBMC). However, Chlamydia infection of other blood cell types, quantification of Chlamydia infected cells in peripheral blood and transmission of this infection in vitro have not been examined. |
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